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PXD029889

PXD029889 is an original dataset announced via ProteomeXchange.

Dataset Summary
TitleEffect of chlorpyrifos on the expression and regulation of salivary gland protein of Haemaphysalis longicornis
DescriptionHaemaphysalis longicornis is a parasitic arthropod on the body surface of vertebrates, which lives by sucking host blood. In addition, H. longicornis can carry and transmit a variety of deadly pathogens to the host. The control of ticks mainly depends on chemical insecticides, among which chlorpyrifos is a common drug to control them. The salivary gland is an important organ to promote the blood-sucking of ticks and regulate the development of ticks, meanwhile, it plays an important role in protecting against pesticides. With the increasing drug resistance of ticks to chlorpyrifos and the harm of the drug to the environment, it is urgent to find other drugs with low toxicity and high efficiency to replace chlorpyrifos. In this study, DIA quantitative proteomics was used to study the dynamic changes of all proteins in the salivary gland of H. longicornis treated with chlorpyrifos. Bioinformatics analysis was used to analyze these proteins, and a variety of proteins that may be involved in the detoxification process were found, such as glutathione S-transferase, glutamine synthase and a variety of heat shock proteins, which provided new molecular targets and ideas for the development of anti-tick vaccines and related drugs.
HostingRepositoryiProX
AnnounceDate2021-11-24
AnnouncementXMLSubmission_2021-11-23_19:14:01.156.xml
DigitalObjectIdentifier
ReviewLevelPeer-reviewed dataset
DatasetOriginOriginal dataset
RepositorySupportUnsupported dataset by repository
PrimarySubmitterNingmei Wang
SpeciesList scientific name: Haemaphysalis longicornis; NCBI TaxID: 44386;
ModificationListNo PTMs are included in the dataset
InstrumentQ Exactive HF
Dataset History
RevisionDatetimeStatusChangeLog Entry
02021-11-23 19:13:26ID requested
12021-11-23 19:14:01announced
Publication List
Dataset with its publication pending
Keyword List
submitter keyword: Haemaphysalis longicornis
Salivary glands
Chlorpyrifos
Quantitative proteomics
Contact List
Hui Wang
contact affiliationHebei Normal University
contact emailwhui1981@163.com
lab head
Ningmei Wang
contact affiliationHebei Normal University
contact email767247571@qq.com
dataset submitter
Full Dataset Link List
iProX dataset URI