PXD029870

PXD029870 is an original dataset announced via ProteomeXchange.

Dataset Summary

Title	Spatial Venomics - Cobra Venom System Reveals Spatial Distinction of Snake Toxins by Mass Spectrometry Imaging
Description	Despite extensive research, there is still limited knowledge of the functional biology of most animal toxins, including their venom production and storage, as well as the morphological structures within sophisticated venom producing tissues that might underpin venom modulation. Here we applied non-targeted mass spectrometry imaging (MSI), in combination with standard proteomic and transcriptomic approaches, to enable discrete toxin mapping in high-resolution intensity maps across a snake venom gland sourced from the Egyptian cobra (Naja haje). Matrix-assisted laser desorption/ionization (MALDI) MSI toxin visualization on the elapid venom gland reveals surprising spatial heterogeneity of different toxin classes at the proteoform level, which may be the result of physiological constraints on venom production and/or storage, or reflect the potential for venom modulation under different stimuli.
HostingRepository	MassIVE
AnnounceDate	2022-02-03
AnnouncementXML	Submission_2022-02-03_05:14:41.237.xml
DigitalObjectIdentifier
ReviewLevel	Non peer-reviewed dataset
DatasetOrigin	Original dataset
RepositorySupport	Supported dataset by repository
PrimarySubmitter	Benjamin Hempel
SpeciesList	scientific name: Naja haje haje; common name: Egyptian cobra; NCBI TaxID: 8642;
ModificationList	No PTMs are included in the dataset
Instrument	rapifleX; impact II

Dataset History

Revision	Datetime	Status	ChangeLog Entry
0	2021-11-22 03:36:07	ID requested
⏵ 1	2022-02-03 05:14:41	announced

Publication List

no publication

no publication

Keyword List

submitter keyword: Spatial Venomics, Mass Spectrometry Imaging, Venom Gland Morphology, Naja, Venom Heterogeneity

submitter keyword: Spatial Venomics, Mass Spectrometry Imaging, Venom Gland Morphology, Naja, Venom Heterogeneity

Contact List

Benjamin-Florian Hempel
contact affiliation	Charite - Universitaetsmedizin Berlin
contact email	benjamin.hempel@charite.de
lab head
Benjamin Hempel
contact affiliation	TU Berlin
contact email	benjamin.hempel@chem.tu-berlin.de
dataset submitter

Full Dataset Link List

MassIVE dataset URI
Dataset FTP location NOTE: Most web browsers have now discontinued native support for FTP access within the browser window. But you can usually install another FTP app (we recommend FileZilla) and configure your browser to launch the external application when you click on this FTP link. Or otherwise, launch an app that supports FTP (like FileZilla) and use this address: ftp://massive.ucsd.edu/MSV000088427/

MassIVE dataset URI

Dataset FTP location
NOTE: Most web browsers have now discontinued native support for FTP access within the browser window. But you can usually install another FTP app (we recommend FileZilla) and configure your browser to launch the external application when you click on this FTP link. Or otherwise, launch an app that supports FTP (like FileZilla) and use this address: ftp://massive.ucsd.edu/MSV000088427/