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PXD029849

PXD029849 is an original dataset announced via ProteomeXchange.

Dataset Summary
TitleClues from the intestinal mucus proteome of Atlantic salmon to counter inflammation
DescriptionIntestinal inflammation in Atlantic salmon was studied by profiling the intestine mucus proteome, employing isobaric tags for relative and absolute quantification and 2D LC-MS/MS approach. Two fish groups were fed soy saponin-containing (inflammation inducer, SO) or devoid (CO) diets for 36 days. Two more fish groups were fed each of the aforementioned diets with a health additive (CP, SP). Inflammation characteristics in the intestine were milder in the SP-fed fish compared to the SO-fed fish, based on histology results. The fish that had intestinal inflammation (SO) was characterised by alterations of many proteins. Based on the enriched KEGG pathways and GO terms of the SO vs CO comparison pathways such as phagosome and lipid binding were affected due to upregulation of protein like Integrin beta 2 precursor, Coronin 1A, Cathepsin S precursor, Vesicle-trafficking protein, and Neutrophil cytosol factors. On the other hand, the SP group had fewer inflammation characteristics and altered proteins; this fish group had higher abundance of protein linked to the pathways aminoacyl-tRNA biosynthesis and ribosome due to the higher abundance of many large and small subunit of ribosomes. The alteration of Glycogen phosphorylase and Glutamin synthetase could also have alleviated intestinal inflammation in the SP group. Elevating the abundance of ribosomal proteins, aminoacyl-tRNA ligases, and lowering the abundance of Glycogen phosphorylase and Glutamine synthetase could be effective to alleviate intestinal inflammation. The proteins described here can be exploited to alleviate intestinal inflammation in fish and higher vertebrates.
HostingRepositoryPRIDE
AnnounceDate2024-10-22
AnnouncementXMLSubmission_2024-10-22_05:32:55.441.xml
DigitalObjectIdentifier
ReviewLevelPeer-reviewed dataset
DatasetOriginOriginal dataset
RepositorySupportUnsupported dataset by repository
PrimarySubmitterKiron Viswanath
SpeciesList scientific name: Salmo salar (Atlantic salmon); NCBI TaxID: 8030;
ModificationListmethylthiolated residue; acetylated residue; monohydroxylated residue
InstrumentTripleTOF 6600
Dataset History
RevisionDatetimeStatusChangeLog Entry
02021-11-20 09:35:37ID requested
12022-02-17 05:59:58announced
22024-10-22 05:33:02announced2024-10-22: Updated project metadata.
Publication List
10.1016/j.jprot.2022.104487;
Kiron V, Kathiresan P, Fernandes JMO, S, ø, rensen M, Vasanth GK, Lin Q, Lin Q, Lim TK, Dahle D, Dias J, Trichet VV, Clues from the intestinal mucus proteome of Atlantic salmon to counter inflammation. J Proteomics, 255():104487(2022) [pubmed]
Keyword List
submitter keyword: aminacyl-tRNA ligases, mucus proteome, Glutamine synthetase,Atlantic salmon, soy saponin, Glycogen phosphorylase, intestinal inflammation, ribosomal proteins
Contact List
Kiron Viswanath
contact affiliationFaculty of Biosciences and Aquaculture, Nord University, Bodø, Norway
contact emailkiron.viswanath@nord.no
lab head
Kiron Viswanath
contact affiliationNord University
contact emailkiron.viswanath@nord.no
dataset submitter
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Dataset FTP location
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