PXD029849

PXD029849 is an original dataset announced via ProteomeXchange.

Title	Clues from the intestinal mucus proteome of Atlantic salmon to counter inflammation
Description	Intestinal inflammation in Atlantic salmon was studied by profiling the intestine mucus proteome, employing isobaric tags for relative and absolute quantification and 2D LC-MS/MS approach. Two fish groups were fed soy saponin-containing (inflammation inducer, SO) or devoid (CO) diets for 36 days. Two more fish groups were fed each of the aforementioned diets with a health additive (CP, SP). Inflammation characteristics in the intestine were milder in the SP-fed fish compared to the SO-fed fish, based on histology results. The fish that had intestinal inflammation (SO) was characterised by alterations of many proteins. Based on the enriched KEGG pathways and GO terms of the SO vs CO comparison pathways such as phagosome and lipid binding were affected due to upregulation of protein like Integrin beta 2 precursor, Coronin 1A, Cathepsin S precursor, Vesicle-trafficking protein, and Neutrophil cytosol factors. On the other hand, the SP group had fewer inflammation characteristics and altered proteins; this fish group had higher abundance of protein linked to the pathways aminoacyl-tRNA biosynthesis and ribosome due to the higher abundance of many large and small subunit of ribosomes. The alteration of Glycogen phosphorylase and Glutamin synthetase could also have alleviated intestinal inflammation in the SP group. Elevating the abundance of ribosomal proteins, aminoacyl-tRNA ligases, and lowering the abundance of Glycogen phosphorylase and Glutamine synthetase could be effective to alleviate intestinal inflammation. The proteins described here can be exploited to alleviate intestinal inflammation in fish and higher vertebrates.
HostingRepository	PRIDE
AnnounceDate	2024-10-22
AnnouncementXML	Submission_2024-10-22_05:32:55.441.xml
DigitalObjectIdentifier
ReviewLevel	Peer-reviewed dataset
DatasetOrigin	Original dataset
RepositorySupport	Unsupported dataset by repository
PrimarySubmitter	Kiron Viswanath
SpeciesList	scientific name: Salmo salar (Atlantic salmon); NCBI TaxID: 8030;
ModificationList	methylthiolated residue; acetylated residue; monohydroxylated residue
Instrument	TripleTOF 6600

Revision	Datetime	Status	ChangeLog Entry
0	2021-11-20 09:35:37	ID requested
1	2022-02-17 05:59:58	announced
⏵ 2	2024-10-22 05:33:02	announced	2024-10-22: Updated project metadata.

10.1016/j.jprot.2022.104487;

Kiron V, Kathiresan P, Fernandes JMO, S, ø, rensen M, Vasanth GK, Lin Q, Lin Q, Lim TK, Dahle D, Dias J, Trichet VV, Clues from the intestinal mucus proteome of Atlantic salmon to counter inflammation. J Proteomics, 255():104487(2022) [pubmed]

submitter keyword: aminacyl-tRNA ligases, mucus proteome, Glutamine synthetase,Atlantic salmon, soy saponin, Glycogen phosphorylase, intestinal inflammation, ribosomal proteins

Kiron Viswanath
contact affiliation	Faculty of Biosciences and Aquaculture, Nord University, Bodø, Norway
contact email	kiron.viswanath@nord.no
lab head
Kiron Viswanath
contact affiliation	Nord University
contact email	kiron.viswanath@nord.no
dataset submitter

Dataset FTP location NOTE: Most web browsers have now discontinued native support for FTP access within the browser window. But you can usually install another FTP app (we recommend FileZilla) and configure your browser to launch the external application when you click on this FTP link. Or otherwise, launch an app that supports FTP (like FileZilla) and use this address: ftp://ftp.pride.ebi.ac.uk/pride/data/archive/2022/02/PXD029849

PRIDE project URI

• PRIDE
  1. PXD029849
     1. Label: PRIDE project
     2. Name: Clues from the intestinal mucus proteome of Atlantic salmon to counter inflammation