PXD029849 is an
original dataset announced via ProteomeXchange.
Dataset Summary
Title | Clues from the intestinal mucus proteome of Atlantic salmon to counter inflammation |
Description | Intestinal inflammation in Atlantic salmon was studied by profiling the intestine mucus proteome, employing isobaric tags for relative and absolute quantification and 2D LC-MS/MS approach. Two fish groups were fed soy saponin-containing (inflammation inducer, SO) or devoid (CO) diets for 36 days. Two more fish groups were fed each of the aforementioned diets with a health additive (CP, SP). Inflammation characteristics in the intestine were milder in the SP-fed fish compared to the SO-fed fish, based on histology results. The fish that had intestinal inflammation (SO) was characterised by alterations of many proteins. Based on the enriched KEGG pathways and GO terms of the SO vs CO comparison pathways such as phagosome and lipid binding were affected due to upregulation of protein like Integrin beta 2 precursor, Coronin 1A, Cathepsin S precursor, Vesicle-trafficking protein, and Neutrophil cytosol factors. On the other hand, the SP group had fewer inflammation characteristics and altered proteins; this fish group had higher abundance of protein linked to the pathways aminoacyl-tRNA biosynthesis and ribosome due to the higher abundance of many large and small subunit of ribosomes. The alteration of Glycogen phosphorylase and Glutamin synthetase could also have alleviated intestinal inflammation in the SP group. Elevating the abundance of ribosomal proteins, aminoacyl-tRNA ligases, and lowering the abundance of Glycogen phosphorylase and Glutamine synthetase could be effective to alleviate intestinal inflammation. The proteins described here can be exploited to alleviate intestinal inflammation in fish and higher vertebrates. |
HostingRepository | PRIDE |
AnnounceDate | 2024-10-22 |
AnnouncementXML | Submission_2024-10-22_05:32:55.441.xml |
DigitalObjectIdentifier | |
ReviewLevel | Peer-reviewed dataset |
DatasetOrigin | Original dataset |
RepositorySupport | Unsupported dataset by repository |
PrimarySubmitter | Kiron Viswanath |
SpeciesList | scientific name: Salmo salar (Atlantic salmon); NCBI TaxID: 8030; |
ModificationList | methylthiolated residue; acetylated residue; monohydroxylated residue |
Instrument | TripleTOF 6600 |
Dataset History
Revision | Datetime | Status | ChangeLog Entry |
0 | 2021-11-20 09:35:37 | ID requested | |
1 | 2022-02-17 05:59:58 | announced | |
⏵ 2 | 2024-10-22 05:33:02 | announced | 2024-10-22: Updated project metadata. |
Publication List
10.1016/j.jprot.2022.104487; |
Kiron V, Kathiresan P, Fernandes JMO, S, ø, rensen M, Vasanth GK, Lin Q, Lin Q, Lim TK, Dahle D, Dias J, Trichet VV, Clues from the intestinal mucus proteome of Atlantic salmon to counter inflammation. J Proteomics, 255():104487(2022) [pubmed] |
Keyword List
submitter keyword: aminacyl-tRNA ligases, mucus proteome, Glutamine synthetase,Atlantic salmon, soy saponin, Glycogen phosphorylase, intestinal inflammation, ribosomal proteins |
Contact List
Kiron Viswanath |
contact affiliation | Faculty of Biosciences and Aquaculture, Nord University, Bodø, Norway |
contact email | kiron.viswanath@nord.no |
lab head | |
Kiron Viswanath |
contact affiliation | Nord University |
contact email | kiron.viswanath@nord.no |
dataset submitter | |
Full Dataset Link List
Dataset FTP location
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PRIDE project URI |
Repository Record List
[ + ]
[ - ]
- PRIDE
- PXD029849
- Label: PRIDE project
- Name: Clues from the intestinal mucus proteome of Atlantic salmon to counter inflammation