PXD029845

PXD029845 is an original dataset announced via ProteomeXchange.

Title	Proteomic profiling of postmortem prefrontal cortex tissue of suicide completers
Description	A total of 36 postmortem brain samples (23 suicide completers, 13 control sudden death) were collected. We evaluated the proteome profile in the prefrontal cortex (Brodmann area 9, 10) with TMT-based quantification using LC-MS/MS. Several bioinformatics tools were used to elucidate biological mechanisms related to suicide. Subgroup analysis was conducted to find common differentially expressed proteins (DEPs) among various clinically different groups. Among the 9801 proteins identified in our dataset, 295 proteins were differentially expressed between suicide completers and sudden death subjects. Various bioinformatics analysis revealed that suicide completion is predominately enriched in synaptic functions and synaptogenesis especially in endocannabinoid and GABA signaling pathway. Our finding presents the largest protein pools related to suicide completion, and suggests that newly emerging neurotransmitter systems such as endocannabinoid system and synaptogenesis processes may have an impact upon the biological cascade leading to suicide.
HostingRepository	PRIDE
AnnounceDate	2022-05-27
AnnouncementXML	Submission_2022-05-27_13:32:52.685.xml
DigitalObjectIdentifier
ReviewLevel	Peer-reviewed dataset
DatasetOrigin	Original dataset
RepositorySupport	Unsupported dataset by repository
PrimarySubmitter	Dongyoon Shin
SpeciesList	scientific name: Homo sapiens (Human); NCBI TaxID: 9606;
ModificationList	No PTMs are included in the dataset
Instrument	Q Exactive

Revision	Datetime	Status	ChangeLog Entry
0	2021-11-20 09:28:36	ID requested
⏵ 1	2022-05-27 13:32:53	announced

Kim MJ, Do M, Han D, Son M, Shin D, Yeo I, Yun YH, Yoo SH, Choi HJ, Shin D, Rhee SJ, Ahn YM, Kim Y, Proteomic profiling of postmortem prefrontal cortex tissue of suicide completers. Transl Psychiatry, 12(1):142(2022) [pubmed]

submitter keyword: postmortem brain, suicide, proteomics, LC-MS/MS, Tandem mass tag

Youngsoo Kim
contact affiliation	Department of Biomedical Sciences, Seoul National University College of Medicine 103 Daehakro Seoul 30380, Korea
contact email	biolab@snu.ac.kr
lab head
Dongyoon Shin
contact affiliation	Seoul National University
contact email	sdymath777@naver.com
dataset submitter

Dataset FTP location NOTE: Most web browsers have now discontinued native support for FTP access within the browser window. But you can usually install another FTP app (we recommend FileZilla) and configure your browser to launch the external application when you click on this FTP link. Or otherwise, launch an app that supports FTP (like FileZilla) and use this address: ftp://ftp.pride.ebi.ac.uk/pride/data/archive/2022/05/PXD029845

PRIDE project URI

• PRIDE
  1. PXD029845
     1. Label: PRIDE project
     2. Name: Proteomic profiling of postmortem prefrontal cortex tissue of suicide completers