PXD029805

PXD029805 is an original dataset announced via ProteomeXchange.

Title	In-depth proteomic analyses reveal unique subtype-specific signatures in small cell lung cancer (part I: cell pellets)
Description	Small-cell lung cancer (SCLC) represents about 13–15% of all lung cancers and with a five-year survival rate of less than 7%, it remains one of the most lethal forms of malignant diseases. It has a very aggressive course and is characterized by extensive chromosomal rearrangements, high mutation burden, and almost universal inactivation of the tumor suppressor genes TP53 and RB1. Therefore, the vast majority of SCLC patients are diagnosed with extensive-stage disease when surgery is not feasible and the treatment options are mostly limited to cytotoxic chemotherapy (CHT) and radiation. Importantly, targeted therapies for these patients have so far failed, and the success of immunotherapy in non-SCLC (NSCLC) has not been reflected in SCLC. Although SCLC has been formerly considered as a homogeneous disease with a single morphological type, recent advances in SCLC research have led to the development of subtype-specific classifications primarily based on neuroendocrine (NE) features and unique molecular profiles. Here, we investigate the general cell line characteristics on protein level, the relationship between the RNA-based classification and the protein expression profile, and the distinct biological processes specific for each subtype.
HostingRepository	PRIDE
AnnounceDate	2023-11-14
AnnouncementXML	Submission_2023-11-14_08:30:57.984.xml
DigitalObjectIdentifier	https://dx.doi.org/10.6019/PXD029805
ReviewLevel	Peer-reviewed dataset
DatasetOrigin	Original dataset
RepositorySupport	Supported dataset by repository
PrimarySubmitter	Nicole Woldmar
SpeciesList	scientific name: Homo sapiens (Human); NCBI TaxID: 9606;
ModificationList	No PTMs are included in the dataset
Instrument	Q Exactive

Revision	Datetime	Status	ChangeLog Entry
0	2021-11-19 00:18:17	ID requested
1	2022-10-14 09:13:55	announced
⏵ 2	2023-11-14 08:30:58	announced	2023-11-14: Updated project metadata.

Szeitz B, Megyesfalvi Z, Woldmar N, Valk, ó Z, Schwendenwein A, B, á, r, á, ny N, Paku S, L, á, szl, ó V, Kiss H, Bugyik E, Lang C, Sz, á, sz AM, Pizzatti L, Bogos K, Hoda MA, Hoetzenecker K, Marko-Varga G, Horvatovich P, D, ö, me B, Schelch K, Rezeli M, In-depth proteomic analysis reveals unique subtype-specific signatures in human small-cell lung cancer. Clin Transl Med, 12(9):e1060(2022) [pubmed]

10.6019/PXD029805;

submitter keyword: SCLC, proteomics, cell lines, molecular subtypes

Melinda Rezeli
contact affiliation	Div. Clinical Protein Science and Imaging, Dept. of Clinical Sciences and Dept. of Biomedical Engineering, Lund University, Sweden
contact email	melinda.rezeli@bme.lth.se
lab head
Nicole Woldmar
contact affiliation	Federal University of Rio de Janeiro (UFRJ)
contact email	nwoldmar@gmail.com
dataset submitter

Dataset FTP location NOTE: Most web browsers have now discontinued native support for FTP access within the browser window. But you can usually install another FTP app (we recommend FileZilla) and configure your browser to launch the external application when you click on this FTP link. Or otherwise, launch an app that supports FTP (like FileZilla) and use this address: ftp://ftp.pride.ebi.ac.uk/pride/data/archive/2022/10/PXD029805

PRIDE project URI

• PRIDE
  1. PXD029805
     1. Label: PRIDE project
     2. Name: In-depth proteomic analyses reveal unique subtype-specific signatures in small cell lung cancer (part I: cell pellets)