PXD029803

PXD029803 is an original dataset announced via ProteomeXchange.

Dataset Summary

Title	MS-CETSA discovery of target engagement by Darapladib
Description	We used the lysate MS-CETSA Isothermal Dose-Response (ITDR) protocol to discover the interactions of Darapladib with proteins in Plasmodium falciparum and human red blood cells proteomes.
HostingRepository	jPOST
AnnounceDate	2022-05-18
AnnouncementXML	Submission_2024-01-04_17:58:18.243.xml
DigitalObjectIdentifier
ReviewLevel	Peer-reviewed dataset
DatasetOrigin	Original dataset
RepositorySupport	Unsupported dataset by repository
PrimarySubmitter	Jerzy Michal Dziekan
SpeciesList	scientific name: Plasmodium falciparum; NCBI TaxID: 5833;
ModificationList	TMT6plex reporter+balance reagent acylated N-terminal; TMT6plex reporter+balance reagent N-acylated residue; S-carboxamidomethyl-L-cysteine; L-methionine sulfoxide; alpha-amino acetylated residue
Instrument	Q Exactive

Dataset History

Revision	Datetime	Status	ChangeLog Entry
0	2021-11-18 21:41:46	ID requested
1	2022-05-17 08:00:06	announced
2	2022-09-18 02:43:14	announced	2022-09-18: Updated FTP location.
⏵ 3	2024-01-04 17:58:19	announced	2024-01-05: Updated PubMed.

Publication List

Wagner MP, Formaglio P, Gorgette O, Dziekan JM, Huon C, Berneburg I, Rahlfs S, Barale JC, Feinstein SI, Fisher AB, M, é, nard D, Bozdech Z, Amino R, Touqui L, Chitnis CE, Human peroxiredoxin 6 is essential for malaria parasites and provides a host-based drug target. Cell Rep, 39(11):110923(2022) [pubmed]

Wagner MP, Formaglio P, Gorgette O, Dziekan JM, Huon C, Berneburg I, Rahlfs S, Barale JC, Feinstein SI, Fisher AB, M, é, nard D, Bozdech Z, Amino R, Touqui L, Chitnis CE, Human peroxiredoxin 6 is essential for malaria parasites and provides a host-based drug target. Cell Rep, 39(11):110923(2022) [pubmed]

Keyword List

submitter keyword: CETSA, TPP, malaria, Plasmodium falciparum, Red Blood Cell, RBC

submitter keyword: CETSA, TPP, malaria, Plasmodium falciparum, Red Blood Cell, RBC

Contact List

Jerzy Michal Dziekan, Zbynek Bozdech
lab head
Jerzy Michal Dziekan
contact affiliation	The Walter and Eliza Hall Institute of Medical Research
dataset submitter

Full Dataset Link List

jPOST dataset URI
Dataset FTP location NOTE: Most web browsers have now discontinued native support for FTP access within the browser window. But you can usually install another FTP app (we recommend FileZilla) and configure your browser to launch the external application when you click on this FTP link. Or otherwise, launch an app that supports FTP (like FileZilla) and use this address: ftp://ftp.jpostdb.org/JPST001368/

jPOST dataset URI

Dataset FTP location
NOTE: Most web browsers have now discontinued native support for FTP access within the browser window. But you can usually install another FTP app (we recommend FileZilla) and configure your browser to launch the external application when you click on this FTP link. Or otherwise, launch an app that supports FTP (like FileZilla) and use this address: ftp://ftp.jpostdb.org/JPST001368/