PXD029760

PXD029760 is an original dataset announced via ProteomeXchange.

Title	Observation of Serum Protein Fingerprints of Coronary Atherosclerotic Heart Disease with Different TCM Syndrome Types Before and After Percutaneous Coronary Intervention
Description	In this study, 227 and 211 patients with CAD-QS and CAD-QD were enrolled, and all patients were treated with PCI. LFQ quantitative proteomics technology was used to analyze the changes of serum protein fingerprints of patients before and 6 months after PCI, to explore the intervention mechanism of PCI on CAD of two different TCM syndromes. Clinical results showed that TNF- α, HDL-C, BSCSO, and Gensini levels were significantly changed in both groups after PCI; Proteomic results showed that there were 79 and 95 DEPs in CAD (QS) and (QD) respectively. Changes in the levels of C8A, CFH, APOH, APOB, PLG, and CFI were found in both groups after PCI, mainly involving biological processes such as complement and coagulation cascade, lipid metabolism, vascular function regulation, immunity and inflammation. In addition, cell adhesion and connection-related processes were found in QS patients after PCI, QD group showed the changes of lipid metabolism-related pathways such as the PPAR signal pathway and ECM receptor interaction after PCI. In conclusion, this study provides information on the changes of serum proteome after CAD QS and QD PCI and provides a reference for further research on CAD proteome and identification of biomarkers related to PCI intervention in CAD subtypes.
HostingRepository	iProX
AnnounceDate	2021-11-16
AnnouncementXML	Submission_2022-11-29_20:06:28.815.xml
DigitalObjectIdentifier
ReviewLevel	Peer-reviewed dataset
DatasetOrigin	Original dataset
RepositorySupport	Unsupported dataset by repository
PrimarySubmitter	Ying Li
SpeciesList	scientific name: Homo sapiens; NCBI TaxID: 9606;
ModificationList	No PTMs are included in the dataset
Instrument	Q Exactive Plus

Revision	Datetime	Status	ChangeLog Entry
0	2021-11-15 22:43:15	ID requested
⏵ 1	2022-11-29 20:06:29	announced

Dataset with its publication pending

submitter keyword: coronary atherosclerotic heart disease, TCM syndrome, percutaneous coronary intervention, proteomics

Jianxun Liu
contact affiliation	Institute of Basic Medical Sciences, Xiyuan Hospital, China Academy of Chinese Medical Sciences
contact email	liujx0324@sina.com
lab head
Ying Li
contact affiliation	Institute of Basic Medical Sciences, Xiyuan Hospital, China Academy of Chinese Medical Sciences
contact email	yingli0815@163.com
dataset submitter

iProX dataset URI