PXD029743

PXD029743 is an original dataset announced via ProteomeXchange.

Title	To identify the nuclear partner(s) of TYRO3 in colon cells using LC-Quadrupole Time-of-Flight Mass Spectrometry.
Description	Colorectal cancer (CRC) is one of the most common death-related cancers worldwide. Aberrant expression of oncogenes is regarded as a predominant factor in CRC development. In our study, we found that TYRO3 intracellular domain nuclear translocation promotes CRC cell proliferation, metastasis, and tumor progression. To identify downstream effector that transmits the cellular functions of nuclear TYRO3, we performed nuclear TYRO3 co-immunoprecipitation.
HostingRepository	PRIDE
AnnounceDate	2023-11-14
AnnouncementXML	Submission_2023-11-14_08:46:20.066.xml
DigitalObjectIdentifier	https://dx.doi.org/10.6019/PXD029743
ReviewLevel	Peer-reviewed dataset
DatasetOrigin	Original dataset
RepositorySupport	Supported dataset by repository
PrimarySubmitter	Pei-Ling Hsu
SpeciesList	scientific name: Homo sapiens (Human); NCBI TaxID: 9606;
ModificationList	No PTMs are included in the dataset
Instrument	impact HD

Revision	Datetime	Status	ChangeLog Entry
0	2021-11-15 05:42:15	ID requested
1	2023-05-10 13:14:09	announced
⏵ 2	2023-11-14 08:46:24	announced	2023-11-14: Updated project metadata.

Hsu PL, Chien CW, Tang YA, Lin BW, Lin SC, Lin YS, Chen SY, Sun HS, Tsai SJ, Targeting BRD3 eradicates nuclear TYRO3-induced colorectal cancer metastasis. Sci Adv, 9(15):eade3422(2023) [pubmed]

10.6019/PXD029743;

ProteomeXchange project tag: Cancer (B/D-HPP), Biology/Disease-Driven Human Proteome Project (B/D-HPP), Human Proteome Project

submitter keyword: TYRO3, LC-Quadrupole Time-of-Flight Mass Spectrometry, human,Colon

Shaw-Jenq Tsai
contact affiliation	Department of Physiology, College of Medicine, National Cheng Kung University, Tainan 70101, Taiwan
contact email	seantsai@ncku.edu.tw
lab head
Pei-Ling Hsu
contact affiliation	Department of Physiology, College of Medicine, National Cheng Kung University
contact email	plhsu@ncku.edu.tw
dataset submitter

Dataset FTP location NOTE: Most web browsers have now discontinued native support for FTP access within the browser window. But you can usually install another FTP app (we recommend FileZilla) and configure your browser to launch the external application when you click on this FTP link. Or otherwise, launch an app that supports FTP (like FileZilla) and use this address: ftp://ftp.pride.ebi.ac.uk/pride/data/archive/2023/05/PXD029743

PRIDE project URI

• PRIDE
  1. PXD029743
     1. Label: PRIDE project
     2. Name: To identify the nuclear partner(s) of TYRO3 in colon cells using LC-Quadrupole Time-of-Flight Mass Spectrometry.