PXD029732

PXD029732 is an original dataset announced via ProteomeXchange.

Title	A Clinical trial ready proteomics workflow to support large-scale analysis of Human Plasma: application to the Fenofibrate Intervention and Event Lowering in Diabetes (FIELD) trial
Description	Background: Proteomic mass spectrometry is widely used to quantify proteins in biological specimens for biomarker discovery. Clinical studies requiring proteomic analysis of plasma are more complicated due to the high dynamic range and abundance of major plasma proteins. There is an unmet need to develop robust, rapid and cost-effective workflows able to support large-scale clinical studies of thousands of plasma specimens. We set about developing a suitable system to be used for the analysis of plasma collected from FIELD trial participants which investigated five years oral fenofibrate on coronary heart disease and microvascular complications.
HostingRepository	PRIDE
AnnounceDate	2023-11-14
AnnouncementXML	Submission_2023-11-14_08:55:39.283.xml
DigitalObjectIdentifier
ReviewLevel	Peer-reviewed dataset
DatasetOrigin	Original dataset
RepositorySupport	Unsupported dataset by repository
PrimarySubmitter	Matthew O'Rourke
SpeciesList	scientific name: Homo sapiens (Human); NCBI TaxID: 9606;
ModificationList	No PTMs are included in the dataset
Instrument	Q Exactive HF

Revision	Datetime	Status	ChangeLog Entry
0	2021-11-12 08:01:28	ID requested
1	2023-09-29 01:16:33	announced
⏵ 2	2023-11-14 08:55:40	announced	2023-11-14: Updated project metadata.

Dataset with its publication pending

submitter keyword: Plasma, DIA, Clinical Trial, Clionical proteomics, Orbitrap

Mark Molloy
contact affiliation	BIomarker and bowel cancer laboratory, Kolling institute of medical research, university of sydney
contact email	m.molloy@sydney.edu.au
lab head
Matthew O'Rourke
contact affiliation	University of Technology Sydney
contact email	matthew.orourke1@gmail.com
dataset submitter

Dataset FTP location NOTE: Most web browsers have now discontinued native support for FTP access within the browser window. But you can usually install another FTP app (we recommend FileZilla) and configure your browser to launch the external application when you click on this FTP link. Or otherwise, launch an app that supports FTP (like FileZilla) and use this address: ftp://ftp.pride.ebi.ac.uk/pride/data/archive/2023/09/PXD029732

PRIDE project URI

• PRIDE
  1. PXD029732
     1. Label: PRIDE project
     2. Name: A Clinical trial ready proteomics workflow to support large-scale analysis of Human Plasma: application to the Fenofibrate Intervention and Event Lowering in Diabetes (FIELD) trial