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PXD029689 is an original dataset announced via ProteomeXchange.

Dataset Summary
TitleAmyloid-like aggregating proteins cause lysosomal defects in neurons via gain-of-function toxicity
DescriptionHere, we combine cryo-electron tomography, proteomics and cell biology studies to investigate the effects of protein aggregates in primary neurons. We use artificial amyloid-like β-sheet proteins (β proteins) to focus on the gain-of-function aspect of aggregation. These proteins form fibrillar aggregates and cause neurotoxicity. We show that late stages of autophagy are impaired by the aggregates, resulting in lysosomal alterations reminiscent of lysosomal storage disorders.
ReviewLevelPeer-reviewed dataset
DatasetOriginOriginal dataset
RepositorySupportUnsupported dataset by repository
PrimarySubmitterDaniel Hornburg
SpeciesList scientific name: Mus musculus (Mouse); NCBI TaxID: 10090;
ModificationListNo PTMs are included in the dataset
InstrumentQ Exactive
Dataset History
RevisionDatetimeStatusChangeLog Entry
02021-11-11 05:59:54ID requested
12021-12-20 11:42:12announced
Publication List
Dataset with its publication pending
Keyword List
submitter keyword: neurodegeneration, protein aggregates, toxic proteins, neurons
Contact List
Daniel Hornburg
contact affiliationStanford
contact emaildaniel.dh.hornburg@gmail.com
lab head
Daniel Hornburg
contact affiliationStanford
contact emaildaniel.dh.hornburg@gmail.com
dataset submitter
Full Dataset Link List
Dataset FTP location
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PRIDE project URI
Repository Record List
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