PXD029680

PXD029680 is an original dataset announced via ProteomeXchange.

Title	System level analysis of insulin action revels insight into whole body metabolism and insulin action in muscle and adipose tissue
Description	Muscle and adipose tissue insulin resistance are major drivers of metabolic disease. To uncover pathways involved in insulin resistance specifically in these tissues, we leveraged the metabolic diversity of different dietary exposures and discrete inbred mouse strains. This revealed that muscle insulin resistance was driven by gene-by-environment interactions and was strongly correlated with hyperinsulinemia and decreased levels of ten key glycolytic enzymes. Remarkably, there was no relationship between muscle and adipose tissue insulin resistance. Adipocyte size profoundly varied across strains and diets, and this was strongly correlated with adipose tissue insulin action. The A/J strain in particular exhibited marked adipocyte insulin resistance and hypertrophy despite robust muscle insulin responsiveness, challenging the role of adipocyte hypertrophy per se in systemic insulin resistance. These data demonstrate that muscle and adipose tissue insulin resistance can occur independently and underscore the need for tissue-specific interrogation to understand metabolic disease.
HostingRepository	PRIDE
AnnounceDate	2023-11-14
AnnouncementXML	Submission_2023-11-14_08:53:55.762.xml
DigitalObjectIdentifier
ReviewLevel	Peer-reviewed dataset
DatasetOrigin	Original dataset
RepositorySupport	Unsupported dataset by repository
PrimarySubmitter	Soren Madsen
SpeciesList	scientific name: Mus musculus (Mouse); NCBI TaxID: 10090;
ModificationList	No PTMs are included in the dataset
Instrument	Q Exactive HF

Revision	Datetime	Status	ChangeLog Entry
0	2021-11-11 05:18:52	ID requested
1	2022-02-23 21:49:55	announced
⏵ 2	2023-11-14 08:53:56	announced	2023-11-14: Updated project metadata.

Dataset with its publication pending

submitter keyword: insulin resistance, seven strains, mouse,soleus muscle

David E. James
contact affiliation	University of Sydney
contact email	david.james@sydney.edu.au
lab head
Soren Madsen
contact affiliation	University of Sydney
contact email	soren.madsen@sydney.edu.au
dataset submitter

Dataset FTP location NOTE: Most web browsers have now discontinued native support for FTP access within the browser window. But you can usually install another FTP app (we recommend FileZilla) and configure your browser to launch the external application when you click on this FTP link. Or otherwise, launch an app that supports FTP (like FileZilla) and use this address: ftp://ftp.pride.ebi.ac.uk/pride/data/archive/2022/02/PXD029680

PRIDE project URI

• PRIDE
  1. PXD029680
     1. Label: PRIDE project
     2. Name: System level analysis of insulin action revels insight into whole body metabolism and insulin action in muscle and adipose tissue