PXD029649

PXD029649 is an original dataset announced via ProteomeXchange.

Title	Quantitative analysis of the global proteome of heart tissue in septic shock
Description	Nowadays, sepsis and septic shock have become major public health problems, which are the main cause of death among patients admitted to the intensive care units. Notably, myocardial dysfunction during sepsis, usually called sepsis-induced myocardial depression, is common in septic shock patients whose incidence is about 70% and leads to a high mortality. However, the mechanism underlying the septic myocardial depression is still unclear. Recently, proteomics has become a powerful method for explore protein dynamics and their complex regulatory mechanism, and thus generates a profound impact on precision medicine and the clinical setting. Importantly, the expression patterns of global proteins in heart tissue between sepsis and control group remain unclear. Therefore, we performed the rat models of sepsis-induced myocardial depression and investigated global protein expression profiles in heart tissue between sepsis and control group using 4D label-free proteomic technique.
HostingRepository	PRIDE
AnnounceDate	2025-05-19
AnnouncementXML	Submission_2025-05-19_02:45:35.315.xml
DigitalObjectIdentifier
ReviewLevel	Peer-reviewed dataset
DatasetOrigin	Original dataset
RepositorySupport	Unsupported dataset by repository
PrimarySubmitter	tiening zhang
SpeciesList	scientific name: Rattus norvegicus (Rat); NCBI TaxID: 10116;
ModificationList	No PTMs are included in the dataset
Instrument	timsTOF Pro

Revision	Datetime	Status	ChangeLog Entry
0	2021-11-10 07:37:57	ID requested
⏵ 1	2025-05-19 02:45:36	announced

10.1016/j.jprot.2022.104599;

Yang N, Wang W, Wen R, Zhang TN, Liu CF, Integrated insights into the mechanisms underlying sepsis-induced myocardial depression using a quantitative global proteomic analysis. J Proteomics, 262():104599(2022) [pubmed]

submitter keyword: shock, sepsis,Proteome, myocardial depression

Tie-Ning Zhang
contact affiliation	Department of Pediatrics, Shengjing Hospital of China Medical University
contact email	cmuztn@vip.qq.com
lab head
tiening zhang
contact affiliation	Department of Pediatrics, PICU, Shengjing Hospital of China Medical University
contact email	cmuztn@vip.qq.com
dataset submitter

Dataset FTP location NOTE: Most web browsers have now discontinued native support for FTP access within the browser window. But you can usually install another FTP app (we recommend FileZilla) and configure your browser to launch the external application when you click on this FTP link. Or otherwise, launch an app that supports FTP (like FileZilla) and use this address: ftp://ftp.pride.ebi.ac.uk/pride/data/archive/2025/05/PXD029649

PRIDE project URI

• PRIDE
  1. PXD029649
     1. Label: PRIDE project
     2. Name: Quantitative analysis of the global proteome of heart tissue in septic shock