PXD029647 is an
original dataset announced via ProteomeXchange.
Dataset Summary
Title | Protein-protein interactions of BRG1 or BRG1-HSA in SW13 cells |
Description | The SWI/SNF complex remodels chromatin in an ATP-dependent manner through the ATPase subunits BRG1 and BRM. Chromatin remodeling alters nucleosome structure to change gene expression, however aberrant remodeling and gene expression can result in cancer. The function and localization on chromatin of the SWI/SNF complex depends on the protein makeup of the complex. Here we report the protein-protein interactions of wild-type BRG1 or mutant BRG1 in which the HSA domain has been deleted (BRG1-HSA). We demonstrate the interaction of BRG1 with most SWI/SNF complex members and a failure of a number of these members to interact with BRG1-HSA. These results demonstrate that the HSA domain of BRG1 is a critical interaction platform for the correct formation of SWI/SNF remodeling complexes. |
HostingRepository | PRIDE |
AnnounceDate | 2023-02-15 |
AnnouncementXML | Submission_2023-02-15_15:40:28.713.xml |
DigitalObjectIdentifier | |
ReviewLevel | Peer-reviewed dataset |
DatasetOrigin | Original dataset |
RepositorySupport | Unsupported dataset by repository |
PrimarySubmitter | JasonWilliams |
SpeciesList | scientific name: Homo sapiens (Human); NCBI TaxID: 9606; |
ModificationList | monohydroxylated residue |
Instrument | Q Exactive |
Dataset History
Revision | Datetime | Status | ChangeLog Entry |
0 | 2021-11-10 07:35:32 | ID requested | |
⏵ 1 | 2023-02-15 15:40:29 | announced | |
Publication List
Dataset with its publication pending |
Keyword List
submitter keyword: Human, BRG1, SWI/SNF, Chromatin, SW13 |
Contact List
Jason GrantWilliams |
contact affiliation | Co-Director – Mass Spectrometry Research and Support Group National Institute of Environmental Health Sciences 111 TW Alexander Drive MD F0-04 Research Triangle Park, North Carolina 27709 Phone: (984) 287-3374 |
contact email | willia56@niehs.nih.gov |
lab head | |
JasonWilliams |
contact affiliation | National Institute of Environmental Health Sciences |
contact email | willia56@niehs.nih.gov |
dataset submitter | |
Full Dataset Link List
Dataset FTP location
NOTE: Most web browsers have now discontinued native support for FTP access within the browser window. But you can usually install another FTP app (we recommend FileZilla) and configure your browser to launch the external application when you click on this FTP link. Or otherwise, launch an app that supports FTP (like FileZilla) and use this address: ftp://ftp.pride.ebi.ac.uk/pride/data/archive/2023/02/PXD029647 |
PRIDE project URI |
Repository Record List
[ + ]
[ - ]
- PRIDE
- PXD029647
- Label: PRIDE project
- Name: Protein-protein interactions of BRG1 or BRG1-HSA in SW13 cells