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PXD029647

PXD029647 is an original dataset announced via ProteomeXchange.

Dataset Summary
TitleProtein-protein interactions of BRG1 or BRG1-HSA in SW13 cells
DescriptionThe SWI/SNF complex remodels chromatin in an ATP-dependent manner through the ATPase subunits BRG1 and BRM. Chromatin remodeling alters nucleosome structure to change gene expression, however aberrant remodeling and gene expression can result in cancer. The function and localization on chromatin of the SWI/SNF complex depends on the protein makeup of the complex. Here we report the protein-protein interactions of wild-type BRG1 or mutant BRG1 in which the HSA domain has been deleted (BRG1-HSA). We demonstrate the interaction of BRG1 with most SWI/SNF complex members and a failure of a number of these members to interact with BRG1-HSA. These results demonstrate that the HSA domain of BRG1 is a critical interaction platform for the correct formation of SWI/SNF remodeling complexes.
HostingRepositoryPRIDE
AnnounceDate2023-02-15
AnnouncementXMLSubmission_2023-02-15_15:40:28.713.xml
DigitalObjectIdentifier
ReviewLevelPeer-reviewed dataset
DatasetOriginOriginal dataset
RepositorySupportUnsupported dataset by repository
PrimarySubmitterJasonWilliams
SpeciesList scientific name: Homo sapiens (Human); NCBI TaxID: 9606;
ModificationListmonohydroxylated residue
InstrumentQ Exactive
Dataset History
RevisionDatetimeStatusChangeLog Entry
02021-11-10 07:35:32ID requested
12023-02-15 15:40:29announced
Publication List
Dataset with its publication pending
Keyword List
submitter keyword: Human, BRG1, SWI/SNF, Chromatin, SW13
Contact List
Jason GrantWilliams
contact affiliationCo-Director – Mass Spectrometry Research and Support Group National Institute of Environmental Health Sciences 111 TW Alexander Drive MD F0-04 Research Triangle Park, North Carolina 27709 Phone: (984) 287-3374
contact emailwillia56@niehs.nih.gov
lab head
JasonWilliams
contact affiliationNational Institute of Environmental Health Sciences
contact emailwillia56@niehs.nih.gov
dataset submitter
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Dataset FTP location
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