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PXD029567

PXD029567 is an original dataset announced via ProteomeXchange.

Dataset Summary
TitleIncreased soluble HLA in COVID-19 present a disease-related, diverse immunopeptidome associated with T cell immunity
DescriptionHLA-presented antigenic peptides are central components of T cell-based immunity in infectious disease. Beside HLA molecules on cell surfaces, soluble HLA molecules (sHLA) are released in the blood suggested to impact cellular immune responses. We demonstrated that sHLA levels were significantly increased in COVID-19 patients and convalescent individuals compared to a control cohort and positively correlated with SARS CoV-2-directed cellular immunity. Of note, patients with severe courses of COVID-19 showed reduced sHLA levels. Mass spectrometry-based characterization of sHLA-bound antigenic peptides, the so called soluble immunopeptidome, revealed a COVID-19-associated increased diversity of HLA-presented peptides and identified a naturally presented SARS-CoV-2-derived peptide from the viral nucleoprotein in the plasma of COVID-19 patients. Interestingly, sHLA serum levels directly correlated with the diversity of the soluble immunopeptidome. Together, these findings suggest an inflammation-driven release of sHLA in COVID-19, directly influencing the diversity of the soluble immunopeptidome with implications for SARS-CoV-2-directed T cell-based immunity and disease outcome.
HostingRepositoryPRIDE
AnnounceDate2023-11-14
AnnouncementXMLSubmission_2023-11-14_08:53:55.557.xml
DigitalObjectIdentifier
ReviewLevelPeer-reviewed dataset
DatasetOriginOriginal dataset
RepositorySupportUnsupported dataset by repository
PrimarySubmitterAnnika Nelde
SpeciesList scientific name: Homo sapiens (Human); NCBI TaxID: 9606;
ModificationListmonohydroxylated residue
InstrumentOrbitrap Fusion Lumos
Dataset History
RevisionDatetimeStatusChangeLog Entry
02021-11-04 10:17:10ID requested
12022-11-23 08:03:55announced
22023-11-14 08:53:56announced2023-11-14: Updated project metadata.
Publication List
Dataset with its publication pending
Keyword List
ProteomeXchange project tag: Covid-19
submitter keyword: COVID-19, immunopeptidome, soluble HLA
Contact List
Juliane S. Walz
contact affiliationClinical Collaboration Unit Translational Immunology, University Hospital Tübingen, Tübingen, Germany
contact emailjuliane.walz@med.uni-tuebingen.de
lab head
Annika Nelde
contact affiliationDepartment of Peptide-based Immunotherapy, University and University Hospital Tübingen, Tübingen, Germany
contact emailannika.nelde@uni-tuebingen.de
dataset submitter
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Dataset FTP location
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