PXD029547

PXD029547 is an original dataset announced via ProteomeXchange.

Title	Neutrophil and monocyte dysfunctional effector response towards bacterial challenge in critically ill COVID-19 patients
Description	In this study, we aim to evaluate the relation between COVID-19 and bacterial secondary superinfections. We assessed the functional responses of neutrophils and monocytes isolated from acute and recovery COVID-19 patients upon bacterial infection using Flow-cytometry and proteomics based assays. Both neutrophils and monocytes showed impared intracellular microbicidal capacity along with a decreased functional response. Determination of plasma cytokines levels showed a significant association of certain cytokines towards secondary bacterial infection.
HostingRepository	PRIDE
AnnounceDate	2021-12-10
AnnouncementXML	Submission_2022-01-11_06:07:27.459.xml
DigitalObjectIdentifier
ReviewLevel	Peer-reviewed dataset
DatasetOrigin	Original dataset
RepositorySupport	Unsupported dataset by repository
PrimarySubmitter	Alejandro Gomez Mejia
SpeciesList	scientific name: Homo sapiens (Human); NCBI TaxID: 9606;
ModificationList	monohydroxylated residue; acetylated residue; iodoacetamide derivatized residue
Instrument	timsTOF Pro

Revision	Datetime	Status	ChangeLog Entry
0	2021-11-03 04:30:26	ID requested
1	2021-12-10 04:23:12	announced
⏵ 2	2022-01-11 06:07:28	announced	2022-01-11: Updated publication reference for PubMed record(s): 35007290.

Mairpady Shambat S, G, ó, mez-Mejia A, Schweizer TA, Huemer M, Chang CC, Acevedo C, Bergada-Pijuan J, Vulin C, Hofmaenner DA, Scheier TC, Hertegonne S, Parietti E, Miroshnikova N, Wendel Garcia PD, Hilty MP, Buehler PK, Schuepbach RA, Brugger SD, Zinkernagel AS, Hyperinflammatory environment drives dysfunctional myeloid cell effector response to bacterial challenge in COVID-19. PLoS Pathog, 18(1):e1010176(2022) [pubmed]

ProteomeXchange project tag: Covid-19

submitter keyword: COVID-19, neutrophils, monocytes, bacterial superinfections, hypercytokinemia, effector response, reactive oxygen species, Staphylococcus aureus, Streptococcus pneumoniae

Annelies S. Zinkernagel
contact affiliation	University Hospital Zurich, Department of Infectious diseases and Hospital Epidemiology, Switzerland
contact email	annelies.zinkernagel@usz.ch
lab head
Alejandro Gomez Mejia
contact affiliation	University Hospital of Zürich
contact email	alejandro.gomezmejia@usz.ch
dataset submitter

Dataset FTP location NOTE: Most web browsers have now discontinued native support for FTP access within the browser window. But you can usually install another FTP app (we recommend FileZilla) and configure your browser to launch the external application when you click on this FTP link. Or otherwise, launch an app that supports FTP (like FileZilla) and use this address: ftp://ftp.pride.ebi.ac.uk/pride/data/archive/2021/12/PXD029547

PRIDE project URI

• PRIDE
  1. PXD029547
     1. Label: PRIDE project
     2. Name: Neutrophil and monocyte dysfunctional effector response towards bacterial challenge in critically ill COVID-19 patients