PXD029488

PXD029488 is an original dataset announced via ProteomeXchange.

Title	iTRAQ-based Proteomics Reveals Candidate Proteins of Fat Deposition in Chinese Indigenous Sheep with Morphologically Different Tails
Description	Chinese indigenous sheep can be classified into two types according to their tail morphology: fat-rumped and thin-tailed sheep, of which the typical breeds are Altay sheep and Tibetan sheep, respectively. To identify the differentially expressed proteins (DEPs) underlying the phenotypic differences between tail types, we used iTRAQ combined with multi-dimensional liquid chromatography tandem mass spectrometry (LC-MS/MS) technology to detect candidate proteins. We then subjected these to a database search, and identified the DEPs. Finally, bioinformatics technology was used to carry out GO functional and KEGG pathway analyses. A total of 3248 proteins were identified, of which 44 were up-regulated and 40 were down-regulated DEPs. Analyzing their GO function terms and KEGG pathways revealed that the functions of these DEPs are mainly binding, catalytic activity, structural molecule activity, molecular function regulator, and transporter activity. Among the genes encoding the DEPs, APOA2, GALK1, ADIPOQ, and NDUFS4 are associated with fat formation and metabolism.
HostingRepository	PRIDE
AnnounceDate	2024-10-08
AnnouncementXML	Submission_2024-10-08_11:38:04.563.xml
DigitalObjectIdentifier
ReviewLevel	Peer-reviewed dataset
DatasetOrigin	Original dataset
RepositorySupport	Unsupported dataset by repository
PrimarySubmitter	Caiye Zhu
SpeciesList	scientific name: Ovis canadensis mexicana; NCBI TaxID: 197782;
ModificationList	No PTMs are included in the dataset
Instrument	6520A Quadrupole Time-of-Flight LC/MS

Revision	Datetime	Status	ChangeLog Entry
0	2021-11-02 03:53:58	ID requested
⏵ 1	2024-10-08 11:38:05	announced

10.3389/fgene.2021.710449;

Zhu C, Cheng H, Li N, Liu T, Ma Y, Isobaric Tags for Relative and Absolute Quantification-Based Proteomics Reveals Candidate Proteins of Fat Deposition in Chinese Indigenous Sheep With Morphologically Different Tails. Front Genet, 12():710449(2021) [pubmed]

submitter keyword: fat deposit,iTRAQ, type of tail, sheep

College of Animal Science and Technology
contact affiliation	College of Animal Science and Technology, Genetic laboratory, Gansu Agricultural University, Lanzhou, 730070, China
contact email	584806546@qq.com
lab head
Caiye Zhu
contact affiliation	College of Animal Science and Technology, Gansu Agricultural University
contact email	584806546@qq.com
dataset submitter

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PRIDE project URI

• PRIDE
  1. PXD029488
     1. Label: PRIDE project
     2. Name: iTRAQ-based Proteomics Reveals Candidate Proteins of Fat Deposition in Chinese Indigenous Sheep with Morphologically Different Tails