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PXD029488

PXD029488 is an original dataset announced via ProteomeXchange.

Dataset Summary
TitleiTRAQ-based Proteomics Reveals Candidate Proteins of Fat Deposition in Chinese Indigenous Sheep with Morphologically Different Tails
DescriptionChinese indigenous sheep can be classified into two types according to their tail morphology: fat-rumped and thin-tailed sheep, of which the typical breeds are Altay sheep and Tibetan sheep, respectively. To identify the differentially expressed proteins (DEPs) underlying the phenotypic differences between tail types, we used iTRAQ combined with multi-dimensional liquid chromatography tandem mass spectrometry (LC-MS/MS) technology to detect candidate proteins. We then subjected these to a database search, and identified the DEPs. Finally, bioinformatics technology was used to carry out GO functional and KEGG pathway analyses. A total of 3248 proteins were identified, of which 44 were up-regulated and 40 were down-regulated DEPs. Analyzing their GO function terms and KEGG pathways revealed that the functions of these DEPs are mainly binding, catalytic activity, structural molecule activity, molecular function regulator, and transporter activity. Among the genes encoding the DEPs, APOA2, GALK1, ADIPOQ, and NDUFS4 are associated with fat formation and metabolism.
HostingRepositoryPRIDE
AnnounceDate2024-10-08
AnnouncementXMLSubmission_2024-10-08_11:38:04.563.xml
DigitalObjectIdentifier
ReviewLevelPeer-reviewed dataset
DatasetOriginOriginal dataset
RepositorySupportUnsupported dataset by repository
PrimarySubmitterCaiye Zhu
SpeciesList scientific name: Ovis canadensis mexicana; NCBI TaxID: 197782;
ModificationListNo PTMs are included in the dataset
Instrument6520A Quadrupole Time-of-Flight LC/MS
Dataset History
RevisionDatetimeStatusChangeLog Entry
02021-11-02 03:53:58ID requested
12024-10-08 11:38:05announced
Publication List
10.3389/fgene.2021.710449;
Zhu C, Cheng H, Li N, Liu T, Ma Y, Isobaric Tags for Relative and Absolute Quantification-Based Proteomics Reveals Candidate Proteins of Fat Deposition in Chinese Indigenous Sheep With Morphologically Different Tails. Front Genet, 12():710449(2021) [pubmed]
Keyword List
submitter keyword: fat deposit,iTRAQ, type of tail, sheep
Contact List
College of Animal Science and Technology
contact affiliationCollege of Animal Science and Technology, Genetic laboratory, Gansu Agricultural University, Lanzhou, 730070, China
contact email584806546@qq.com
lab head
Caiye Zhu
contact affiliationCollege of Animal Science and Technology, Gansu Agricultural University
contact email584806546@qq.com
dataset submitter
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Dataset FTP location
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