PXD029454

PXD029454 is an original dataset announced via ProteomeXchange.

Title	Transcriptional repression activity of androgen receptor targets cell plasticity in prostate cancer: BioID analysis
Description	Androgen receptor (AR) signaling remains the key therapeutic target in the management of hormone-naïve advanced prostate cancer (PCa) and castration-resistant PCa (CRPC). Recently, landmark molecular features have been reported for CRPC, including the expression of constitutively active AR variants that lack the ligand-binding domain. Besides their role in CRPC, AR variants lead to the expression of genes involved in tumor progression. However, little is known about the specificity of their mode of action compared with that of wild-type AR (AR-WT). We performed AR transcriptome analyses in an androgen-dependent PCa cell line as well as cross-analyses with publicly available RNA-seq dataset and established that transcriptional repression capacity that was marked for AR-WT was pathologically lost by AR variants. Functional enrichment analyses allowed us to associate AR-WT repressive function to a panel of genes involved in cell adhesion and epithelial-to-mesenchymal transition. So, we postulate that a less documented AR-WT normal function in prostate epithelial cells could be the repression of a panel of genes linked to cell plasticity, and that this repressive function could be pathologically abrogated by AR variants in PCA.
HostingRepository	PRIDE
AnnounceDate	2023-11-14
AnnouncementXML	Submission_2023-11-14_07:56:34.348.xml
DigitalObjectIdentifier
ReviewLevel	Peer-reviewed dataset
DatasetOrigin	Original dataset
RepositorySupport	Unsupported dataset by repository
PrimarySubmitter	Luc Negroni
SpeciesList	scientific name: Homo sapiens (Human); NCBI TaxID: 9606;
ModificationList	No PTMs are included in the dataset
Instrument	LTQ Orbitrap Elite

Revision	Datetime	Status	ChangeLog Entry
0	2021-11-01 04:59:19	ID requested
1	2022-10-13 19:29:18	announced
⏵ 2	2023-11-14 07:56:35	announced	2023-11-14: Updated project metadata.

Erdmann É, Ould Madi Berth, é, l, é, my P, Cottard F, Angel CZ, Schreyer E, Ye T, Morlet B, Negroni L, Kieffer B, C, é, raline J, Androgen receptor-mediated transcriptional repression targets cell plasticity in prostate cancer. Mol Oncol, 16(13):2518-2536(2022) [pubmed]

submitter keyword: Androgen receptor

AR-V7

Cell plasticity

Prostate cancer

EMT

Transcriptional repression

Jocelyn Céraline
contact affiliation	ICANS - FMTS - IGBMC - University of Strasbourg - France
contact email	ceraline@unistra.fr
lab head
Luc Negroni
contact affiliation	CNRS
contact email	luc.negroni@igbmc.fr
dataset submitter

Dataset FTP location NOTE: Most web browsers have now discontinued native support for FTP access within the browser window. But you can usually install another FTP app (we recommend FileZilla) and configure your browser to launch the external application when you click on this FTP link. Or otherwise, launch an app that supports FTP (like FileZilla) and use this address: ftp://ftp.pride.ebi.ac.uk/pride/data/archive/2022/10/PXD029454

PRIDE project URI

• PRIDE
  1. PXD029454
     1. Label: PRIDE project
     2. Name: Transcriptional repression activity of androgen receptor targets cell plasticity in prostate cancer: BioID analysis