PXD029449

PXD029449 is an original dataset announced via ProteomeXchange.

Title	Global profiling of AMG510 modified proteins identified tumor suppressor KEAP1 as an off-target
Description	Here, we presented a streamlined workflow to measure abundant AMG510 modified peptides including that of KRAS/G12C by direct profiling, and a pan-AMG510 antibody peptide IP workflow to profile less abundant AMG510 off-targets.
HostingRepository	iProX
AnnounceDate	2023-01-11
AnnouncementXML	Submission_2023-05-05_21:53:49.319.xml
DigitalObjectIdentifier
ReviewLevel	Peer-reviewed dataset
DatasetOrigin	Original dataset
RepositorySupport	Unsupported dataset by repository
PrimarySubmitter	Bowen Zhong
SpeciesList	scientific name: Homo sapiens; NCBI TaxID: 9606;
ModificationList	No PTMs are included in the dataset
Instrument	Orbitrap Fusion

Revision	Datetime	Status	ChangeLog Entry
0	2021-10-31 20:38:39	ID requested
1	2021-10-31 20:38:53	announced
⏵ 2	2023-05-05 21:53:50	announced	2023-05-06: Update publication information.

Wang Y, Zhong B, Xu C, Zhan D, Zhao S, Wu H, Liu M, Lan X, Cai D, Ding Q, Zheng B, Lan J, Lv Q, Wang Y, Qin J, Global profiling of AMG510 modified proteins identified tumor suppressor KEAP1 as an off-target. iScience, 26(2):106080(2023) [pubmed]

submitter keyword: AMG510

Jun Qin
contact affiliation	National Center for Protein Sciences, Beijing
contact email	jqin1965@126.com
lab head
Bowen Zhong
contact affiliation	National Center for Protein Sciences, Beijing
contact email	582904465@qq.com
dataset submitter

iProX dataset URI