PXD029387
PXD029387 is an original dataset announced via ProteomeXchange.
Dataset Summary
| Title | Truncated titin detection in TTNtv positive DCM human myocardium via patient and allele specific proteomics. |
| Description | Premature termination codons in the gene coding for titin are known to cause dilated cardiomyopathy in humans, but it has been unclear whether or not the expected truncated protein is expressed in the human heart, potentially causing DCM. We have shown using per patient allele specific proteomics that truncated titin is expressed in human myocardium in patients with truncations in those exons retained in the spliced titin transcript. Proteomics were run at Taplin Mass Spectrometry Facility, Harvard University. Filename denotes patient number-gel slice-enzyme-fileID See: Q. McAfee et al., Sci. Transl. Med.10.1126/scitranslmed.abd7287 for a complete description of the experiment. |
| HostingRepository | MassIVE |
| AnnounceDate | 2021-10-28 |
| AnnouncementXML | Submission_2021-10-28_07:00:26.458.xml |
| DigitalObjectIdentifier | |
| ReviewLevel | Non peer-reviewed dataset |
| DatasetOrigin | Original dataset |
| RepositorySupport | Supported dataset by repository |
| PrimarySubmitter | Quentin McAfee |
| SpeciesList | scientific name: Homo sapiens; common name: human; NCBI TaxID: 9606; |
| ModificationList | No PTMs are included in the dataset |
| Instrument | instrument model |
Dataset History
| Revision | Datetime | Status | ChangeLog Entry |
|---|---|---|---|
| 0 | 2021-10-27 22:03:22 | ID requested | |
| ⏵ 1 | 2021-10-28 07:00:30 | announced |
Publication List
| no publication |
Keyword List
| submitter keyword: Titin, Truncation , Premature stop , dilated cardiomyopathy (DCM), allele specific , Heart , myocardium, cardiac, sarcomere, dominant negative |
Contact List
| Zolt Arany | |
|---|---|
| contact affiliation | University of Pennsylvania |
| contact email | Zarany@pennmedicine.upenn.edu |
| lab head | |
| Benjamin Prosser | |
| contact affiliation | University of Pennsylvania |
| contact email | bpros@pennmedicine.upenn.edu |
| lab head | |
| Quentin McAfee | |
| contact affiliation | University of Pennsylvania |
| contact email | qmcafee@pennmedicine.upenn.edu |
| dataset submitter | |
Full Dataset Link List
| MassIVE dataset URI |
| Dataset FTP location NOTE: Most web browsers have now discontinued native support for FTP access within the browser window. But you can usually install another FTP app (we recommend FileZilla) and configure your browser to launch the external application when you click on this FTP link. Or otherwise, launch an app that supports FTP (like FileZilla) and use this address: ftp://massive.ucsd.edu/MSV000088275/ |
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