PXD029380

PXD029380 is an original dataset announced via ProteomeXchange.

Title	Proteome analysis of microvessels from CAA and AD patients
Description	Cerebral amyloid angiopathy (CAA) is an age-related condition and a major cause of intracerebral hemorrhage and cognitive decline that shows close links with Alzheimer's disease (AD). CAA is characterized by the aggregation of amyloid-β (Aβ) peptides and formation of Aβ deposits in the brain vasculature resulting in a disruption of the angioarchitecture. Capillaries are a critical site of Aβ pathology in CAA type 1 and become dysfunctional during disease progression. Here, applying an advanced protocol for the isolation of parenchymal microvessels from post-mortem brain tissue combined with liquid chromatography tandem mass spectrometry (LC-MS/MS), we determined the proteomes of CAA type 1 cases (n = 12) including a patient with hereditary cerebral hemorrhage with amyloidosis-Dutch type (HCHWA-D), and of AD cases without microvascular amyloid pathology (n = 13) in comparison to neurologically healthy controls (n = 12).
HostingRepository	PRIDE
AnnounceDate	2022-03-11
AnnouncementXML	Submission_2022-03-11_06:58:45.755.xml
DigitalObjectIdentifier
ReviewLevel	Peer-reviewed dataset
DatasetOrigin	Original dataset
RepositorySupport	Unsupported dataset by repository
PrimarySubmitter	Andreas Zellner
SpeciesList	scientific name: Homo sapiens (Human); NCBI TaxID: 9606;
ModificationList	acetylated residue; monohydroxylated residue; iodoacetamide derivatized residue
Instrument	Q Exactive HF-X

Revision	Datetime	Status	ChangeLog Entry
0	2021-10-27 08:13:55	ID requested
1	2022-02-16 10:53:30	announced
⏵ 2	2022-03-11 06:58:46	announced	2022-03-11: Updated project metadata.

Zellner A, M, ü, ller SA, Lindner B, Beaufort N, Rozemuller AJM, Arzberger T, Gassen NC, Lichtenthaler SF, Kuster B, Haffner C, Dichgans M, Proteomic profiling in cerebral amyloid angiopathy reveals an overlap with CADASIL highlighting accumulation of HTRA1 and its substrates. Acta Neuropathol Commun, 10(1):6(2022) [pubmed]

ProteomeXchange project tag: Protein Misfolding and Aggregation (B/D-HPP), Biology/Disease-Driven Human Proteome Project (B/D-HPP)

submitter keyword: proteomics,cerebral amyloid angiopathy, CADASIL, cerebral small vessel disease, proteostasis, HTRA1

Bernhard Kuster
contact affiliation	Chair of Proteomics and Bioanalytics, Technical University of Munich (TUM), Freising, Germany
contact email	kuster@tum.de
lab head
Andreas Zellner
contact affiliation	Chair of Proteomics and Bioanalytics, Technical University of Munich (TUM), Freising, Germany
contact email	Andreas.Zellner@tum.de
dataset submitter

Dataset FTP location NOTE: Most web browsers have now discontinued native support for FTP access within the browser window. But you can usually install another FTP app (we recommend FileZilla) and configure your browser to launch the external application when you click on this FTP link. Or otherwise, launch an app that supports FTP (like FileZilla) and use this address: ftp://ftp.pride.ebi.ac.uk/pride/data/archive/2022/02/PXD029380

PRIDE project URI

• PRIDE
  1. PXD029380
     1. Label: PRIDE project
     2. Name: Proteome analysis of microvessels from CAA and AD patients