PXD029370

PXD029370 is an original dataset announced via ProteomeXchange.

Title	Digoxin induces astrocyte activation into a human in vitro astrocyte model
Description	In this study we have evaluated the effect of digoxin in human astrocytes. Our results have shown that non-cytotoxic concentration of digoxin is able to induce astrocytes activation, by affecting cytoskeleton proteins, increasing the expression of pro-inflammatory genes and altering energy metabolism pathways between other mechanisms.
HostingRepository	PRIDE
AnnounceDate	2023-11-14
AnnouncementXML	Submission_2023-11-14_08:23:55.648.xml
DigitalObjectIdentifier
ReviewLevel	Peer-reviewed dataset
DatasetOrigin	Original dataset
RepositorySupport	Unsupported dataset by repository
PrimarySubmitter	Tatjana Vujic
SpeciesList	scientific name: Homo sapiens (Human); NCBI TaxID: 9606;
ModificationList	acetylated residue; iodoacetic acid derivatized residue; iodoacetamide derivatized residue
Instrument	Orbitrap Fusion Lumos

Revision	Datetime	Status	ChangeLog Entry
0	2021-10-27 01:26:28	ID requested
1	2023-03-10 18:13:49	announced
⏵ 2	2023-11-14 08:23:59	announced	2023-11-14: Updated project metadata.

Pamies D, Vuji, ć T, Schvartz D, Boccard J, Repond C, Nunes C, Rudaz S, Sanchez JC, Gonz, á, lez-Ruiz V, Zurich MG, Digoxin Induces Human Astrocyte Reaction In Vitro. Mol Neurobiol, 60(1):84-97(2023) [pubmed]

submitter keyword: Neurotoxicty, astrocytes, neuroinflammation, energy metabolism, astrogliosis, glycolysis

Jean-Charles Sanchez
contact affiliation	Translational Biomarker Group, University of Geneva, Geneva, Switzerland
contact email	Jean-Charles.Sanchez@unige.ch
lab head
Tatjana Vujic
contact affiliation	Department of Medicine, University of Geneva, Geneva, Switzerland
contact email	tatjana.vujic@unige.ch
dataset submitter

Dataset FTP location NOTE: Most web browsers have now discontinued native support for FTP access within the browser window. But you can usually install another FTP app (we recommend FileZilla) and configure your browser to launch the external application when you click on this FTP link. Or otherwise, launch an app that supports FTP (like FileZilla) and use this address: ftp://ftp.pride.ebi.ac.uk/pride/data/archive/2023/03/PXD029370

PRIDE project URI

• PRIDE
  1. PXD029370
     1. Label: PRIDE project
     2. Name: Digoxin induces astrocyte activation into a human in vitro astrocyte model