PXD029366

PXD029366 is an original dataset announced via ProteomeXchange.

Title	Comparative Analysis Reveals Genotype-specific Lyisne Malonylation of Toxoplasma gondii
Description	Toxoplasma gondii is a protozoan parasite which can infect a wide range of animals, including humans. According to virulence, it is generally divided into three different strains, namely type I (RH strain), type II (PRU strain) and type III (VEG strain). Lysine malonylation (Kmal) is a new type of post-translational modification (PTM), which has been reported to regulate diverse biological pathways in various organisms, including T. gondii. However, there is no knowledge about whether lysine malonylation regulates the virulence of different strains in T. gondii. In this study, for the first time, we identified and quantified lysine malonylation level in three strains of T. gondii. In total, 111 proteins and 152 sites were up-regulated, 17 proteins and sites were down-regulated in RH compared with PRU strains, respectively; 50 proteins and 59 sites were up-regulated, 50 proteins and 53 sites were down-regulated in RH strain compared with VEG strains; 72 proteins and 90 sites were up-regulated, 7 proteins and 8 sites were down-regulated in VEG strain compared with PRU strains. Further analysis indicates that these proteins are involved in many important biological processes and regulating virulence-related functions of T. gondii. These findings provide novel and important resource for the role of lysine malonytion in virulence of T. gondii and provide a new direction for the research of vaccine in T. gondii.
HostingRepository	PRIDE
AnnounceDate	2022-05-11
AnnouncementXML	Submission_2022-05-10_18:14:03.472.xml
DigitalObjectIdentifier
ReviewLevel	Peer-reviewed dataset
DatasetOrigin	Original dataset
RepositorySupport	Unsupported dataset by repository
PrimarySubmitter	Lan-Be Nie
SpeciesList	scientific name: Toxoplasma gondii VEG; NCBI TaxID: 432359;
ModificationList	N6-malonyl-L-lysine
Instrument	Bruker Daltonics BioTOF series

Revision	Datetime	Status	ChangeLog Entry
0	2021-10-26 22:58:03	ID requested
⏵ 1	2022-05-10 18:14:03	announced

Dataset with its publication pending

submitter keyword: Toxoplasma gondii, genotype, lysine malonylation, differentially expressed proteins (DEPs)

xing-quan zhu
contact affiliation	State Key Laboratory of Veterinary Etiological Biology, Key Laboratory of Veterinary Parasitology of Gansu Province, Lanzhou Veterinary Research Institute, Chinese Academy of Agricultural Sciences, Lanzhou, Gansu Province 730046, PR China
contact email	xingquanzhu1@hotmail.com
lab head
Lan-Be Nie
contact affiliation	State Key Laboratory of Veterinary Etiological Biology, Key Laboratory of Veterinary Parasitology of Gansu Province, Lanzhou Veterinary Research Institute, Chinese Academy of Agricultural Sciences, Lanzhou
contact email	nielanbi188@163.com
dataset submitter

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PRIDE project URI

• PRIDE
  1. PXD029366
     1. Label: PRIDE project
     2. Name: Comparative Analysis Reveals Genotype-specific Lyisne Malonylation of Toxoplasma gondii