PXD029352

PXD029352 is an original dataset announced via ProteomeXchange.

Title	Complexome profiling of mitochondria to study organismic consequences of aging in Podospora anserina
Description	Podospora anserina is an established aging model with a strong mitochondrial etiology of aging. Here we performed a complexome analysis of isolated mitochondria to study age-related changes of assembled mitochondrial protein complexes. The analysis revealed prominent age-related alterations in oxidative phosphorylation (OXPHOS) and the induction of non-mitochondrial salvage pathways.
HostingRepository	PRIDE
AnnounceDate	2022-02-22
AnnouncementXML	Submission_2022-02-22_04:30:40.068.xml
DigitalObjectIdentifier
ReviewLevel	Peer-reviewed dataset
DatasetOrigin	Original dataset
RepositorySupport	Unsupported dataset by repository
PrimarySubmitter	Ilka Wittig
SpeciesList	scientific name: Podospora anserina; NCBI TaxID: 2587412;
ModificationList	iodoacetamide derivatized residue
Instrument	Q Exactive

Revision	Datetime	Status	ChangeLog Entry
0	2021-10-26 01:24:17	ID requested
⏵ 1	2022-02-22 04:30:40	announced

Warnsmann V, Meisterknecht J, Wittig I, Osiewacz HD, Leads to Alterations of OXPHOS and the Induction of Non-Mitochondrial Salvage Pathways. Cells, 10(12):(2021) [pubmed]

submitter keyword: Podospora anserina, aging, mitochondria, LC-MSMS, complexome profiling, oxidative phosphorylation system

Heinz D. Osiewacz
contact affiliation	Institute of Molecular Biosciences, Faculty of Biosciences, Goethe-University; Frankfurt am Main, Germany
contact email	osiewacz@bio.uni-frankfurt.de
lab head
Ilka Wittig
contact affiliation	Functional Proteomics, Goethe University, Frankfurt am Main , Germany
contact email	wittig@med.uni-frankfurt.de
dataset submitter

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PRIDE project URI

• PRIDE
  1. PXD029352
     1. Label: PRIDE project
     2. Name: Complexome profiling of mitochondria to study organismic consequences of aging in Podospora anserina