PXD029350

PXD029350 is an original dataset announced via ProteomeXchange.

Title	Multiplexed isobaric quantitative cross-linking reveals drug-induced interactome changes in breast cancer cells
Description	In vivo application of an extended set of six iqPIR reagents (6-plex iqPIR) allowing multiplexed quantitative interactome analysis of up to six biological samples in a single LC-MS acquisition. Multiplexed iqPIR is demonstrated on MCF-7 breast cancer cells treated with five different Hsp90 inhibitors revealing large scale protein conformational and interaction changes specific to the molecular class of the inhibitors.
HostingRepository	PRIDE
AnnounceDate	2023-11-14
AnnouncementXML	Submission_2023-11-14_08:24:01.748.xml
DigitalObjectIdentifier
ReviewLevel	Peer-reviewed dataset
DatasetOrigin	Original dataset
RepositorySupport	Unsupported dataset by repository
PrimarySubmitter	Helisa Wippel
SpeciesList	scientific name: Homo sapiens (Human); NCBI TaxID: 9606;
ModificationList	No PTMs are included in the dataset
Instrument	Q Exactive HF

Revision	Datetime	Status	ChangeLog Entry
0	2021-10-26 01:24:00	ID requested
1	2023-03-10 19:08:32	announced
⏵ 2	2023-11-14 08:24:02	announced	2023-11-14: Updated project metadata.

Wippel HH, Chavez JD, Keller AD, Bruce JE, Multiplexed Isobaric Quantitative Cross-Linking Reveals Drug-Induced Interactome Changes in Breast Cancer Cells. Anal Chem, 94(6):2713-2722(2022) [pubmed]

submitter keyword: cross-linking, mass spectrometry,breast cancer

James E. Bruce
contact affiliation	Genome Sciences, Bruce Lab, University of Washington, USA.
contact email	jimbruce@uw.edu
lab head
Helisa Wippel
contact affiliation	University of Washington
contact email	hwippel@uw.edu
dataset submitter

Dataset FTP location NOTE: Most web browsers have now discontinued native support for FTP access within the browser window. But you can usually install another FTP app (we recommend FileZilla) and configure your browser to launch the external application when you click on this FTP link. Or otherwise, launch an app that supports FTP (like FileZilla) and use this address: ftp://ftp.pride.ebi.ac.uk/pride/data/archive/2023/03/PXD029350

PRIDE project URI

• PRIDE
  1. PXD029350
     1. Label: PRIDE project
     2. Name: Multiplexed isobaric quantitative cross-linking reveals drug-induced interactome changes in breast cancer cells