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PXD029341

PXD029341 is an original dataset announced via ProteomeXchange.

Dataset Summary
TitleThe IPF fibroblastic focus is an active collagen biosynthesis factory embedded in a distinct extracellular matrix
DescriptionThe Fibroblastic Focus (FF) is a lesion typical of Idiopathic Pulmonary Fibrosis (IPF). It is the site of myofibroblast accumulation and extracellular matrix (ECM) production. The molecular composition and function of the FF and surrounding tissue remain undefined. Utilizing laser capture microdissection coupled mass spectrometry (LCM-MS), we interrogate the FF, adjacent mature scar tissue, and adjacent alveoli in 6 IPF specimens. To serve as a control, we perform LCM-MS on alveoli from 6 non-fibrotic controls.
HostingRepositoryPRIDE
AnnounceDate2022-08-31
AnnouncementXMLSubmission_2022-08-31_04:52:46.392.xml
DigitalObjectIdentifier
ReviewLevelPeer-reviewed dataset
DatasetOriginOriginal dataset
RepositorySupportUnsupported dataset by repository
PrimarySubmitterCraig Lawless
SpeciesList scientific name: Homo sapiens (Human); NCBI TaxID: 9606;
ModificationListacetylated residue; monohydroxylated residue; iodoacetamide derivatized residue
InstrumentQ Exactive HF
Dataset History
RevisionDatetimeStatusChangeLog Entry
02021-10-25 06:48:20ID requested
12022-08-31 04:52:47announced
Publication List
Herrera JA, Dingle L, Montero MA, Venkateswaran RV, Blaikley JF, Lawless C, Schwartz MA, The UIP/IPF fibroblastic focus is a collagen biosynthesis factory embedded in a distinct extracellular matrix. JCI Insight, 7(16):(2022) [pubmed]
Keyword List
submitter keyword: Human, IPF, Collagen, fibroblastic focus
Contact List
Jeremy Herrera
contact affiliationThe Wellcome Centre for Cell-Matrix Research, University of Manchester, Manchester, UK
contact emailJeremy.Herrera@manchester.ac.uk
lab head
Craig Lawless
contact affiliationUniversity of Manchester
contact emailcraig.lawless@manchester.ac.uk
dataset submitter
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Dataset FTP location
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