PXD029311 is an
original dataset announced via ProteomeXchange.
Dataset Summary
Title | The potential of remdesivir to affect function, metabolism and proliferation of in vitro heart and kidney models |
Description | Here, we performed an in vitro toxicity assessment for remdesivir at clinically relevant concentrations around the cmax of 9 µM using H9c2 rat cardiomyoblasts and neonatal mouse cardiomyocytes (NMCM) as heart models and rat NRK-52E cells and human RPTEC/TERT1 cells as kidney models. Due to the tendency of nucleoside analogs for mitochondrial toxicity, we focused on metabolic changes and mitochondrial function. Additionally, we analyzed the functionality of NMCM and determined early proteomic changes. |
HostingRepository | PRIDE |
AnnounceDate | 2022-05-24 |
AnnouncementXML | Submission_2022-05-24_01:24:24.760.xml |
DigitalObjectIdentifier | |
ReviewLevel | Peer-reviewed dataset |
DatasetOrigin | Original dataset |
RepositorySupport | Unsupported dataset by repository |
PrimarySubmitter | Laxmikanth Kollipara |
SpeciesList | scientific name: Mus musculus (Mouse); NCBI TaxID: 10090; scientific name: Homo sapiens (Human); NCBI TaxID: 9606; |
ModificationList | monohydroxylated residue; iodoacetamide derivatized residue |
Instrument | Q Exactive |
Dataset History
Revision | Datetime | Status | ChangeLog Entry |
0 | 2021-10-25 00:02:13 | ID requested | |
⏵ 1 | 2022-05-24 01:24:25 | announced | |
Publication List
Merches K, Breunig L, Fender J, Brand T, B, ä, tz V, Idel S, Kollipara L, Reinders Y, Sickmann A, Mally A, Lorenz K, The potential of remdesivir to affect function, metabolism and proliferation of cardiac and kidney cells in vitro. Arch Toxicol, 96(8):2341-2360(2022) [pubmed] |
Keyword List
submitter keyword: remdesivir, cardiotoxicity, nephrotoxicity, Covid-19, nucleoside analogue, mitochondrial toxicity |
Contact List
Prof. Dr. Albert Sickmann |
contact affiliation | Leibniz-Institut für Analytische Wissenschaften – ISAS – e.V. Otto-Hahn-Straße 6b 44227 Dortmund, Germany P: +49 (0)2 31.13 92-100 F: +49 (0)2 31.13 92-200 albert.sickmann@isas.de www.isas.de twitter.com/isas_Leibniz |
contact email | albert.sickmann@isas.de |
lab head | |
Laxmikanth Kollipara |
contact affiliation | Leibniz – Institut für Analytische Wissenschaften - ISAS - e.V. |
contact email | laxmikanth.kollipara@isas.de |
dataset submitter | |
Full Dataset Link List
Dataset FTP location
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PRIDE project URI |
Repository Record List
[ + ]
[ - ]
- PRIDE
- PXD029311
- Label: PRIDE project
- Name: The potential of remdesivir to affect function, metabolism and proliferation of in vitro heart and kidney models