PXD029264

PXD029264 is an original dataset announced via ProteomeXchange.

Title	Perception of a conserved family of plant signaling peptides by the receptor kinase HSL3
Description	Plant genomes encode hundreds of secreted peptides; however, relatively few have been characterised. We report here an uncharacterised, stress-induced family of plant signalling peptides, which we call CTNIPs. Based on the role of the common co-receptor BRASSINOSTEROID INSENSITIVE 1-ASSOCIATED KINASE 1 (BAK1) in CTNIP-induced responses, we identified the orphan receptor kinase HAESA-LIKE 3 (HSL3) as the CTNIP receptor via a proteomics approach. CTNIP binding, ligand-triggered complex formation with BAK1, and induced downstream responses all involve HSL3. Notably, the HSL3-CTNIP signalling module is evolutionary ancient, predating the divergence of extant angiosperms. Definition of this signalling module will help establish its physiological role and provides a resource to understand further receptor-ligand co-evolution.
HostingRepository	PRIDE
AnnounceDate	2024-10-07
AnnouncementXML	Submission_2024-10-07_10:57:09.271.xml
DigitalObjectIdentifier	https://dx.doi.org/10.6019/PXD029264
ReviewLevel	Peer-reviewed dataset
DatasetOrigin	Original dataset
RepositorySupport	Supported dataset by repository
PrimarySubmitter	FRank Menke
SpeciesList	scientific name: Arabidopsis thaliana (Mouse-ear cress); NCBI TaxID: 3702;
ModificationList	monohydroxylated residue; iodoacetamide derivatized residue
Instrument	Orbitrap Fusion

Revision	Datetime	Status	ChangeLog Entry
0	2021-10-21 05:07:42	ID requested
⏵ 1	2024-10-07 10:57:10	announced

10.6019/PXD029264;

10.7554/elife.74687;

Rhodes J, Roman AO, Bjornson M, Brandt B, Derbyshire P, Wyler M, Schmid MW, Menke FLH, Santiago J, Zipfel C, Perception of a conserved family of plant signalling peptides by the receptor kinase HSL3. Elife, 11():(2022) [pubmed]

submitter keyword: receptor, immunity, arabidopsis

Frank L.H. Menke
contact affiliation	The Sainsbury Laboratory
contact email	frank.menke@tsl.ac.uk
lab head
FRank Menke
contact affiliation	the Sainsbury laboratory
contact email	Frank.Menke@tsl.ac.uk
dataset submitter

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PRIDE project URI

• PRIDE
  1. PXD029264
     1. Label: PRIDE project
     2. Name: Perception of a conserved family of plant signaling peptides by the receptor kinase HSL3