PXD029261 is an
original dataset announced via ProteomeXchange.
Dataset Summary
| Title | Impact of hormone-sensitive lipase depletion on adipocyte secretome |
| Description | Hormone-sensitive lipase (HSL) is an enzyme involved in the breakdown of triacylglycerols into fatty acids, a catabolic pathway called lipolysis. Out of all mammalian cells, adipocytes express the highest levels of HSL. To explore the roles of HSL beyond adipocyte lipolysis, we performed transcriptional profiling in a human adipocyte model with siRNA-mediated depletion of HSL We observed that expression of genes involved in extracellular matrix remodeling were reduced. The project aimed at determining whether changes in mRNA levels translated into changes in secreted protein levels. |
| HostingRepository | PRIDE |
| AnnounceDate | 2026-01-30 |
| AnnouncementXML | Submission_2026-01-30_04:23:08.020.xml |
| DigitalObjectIdentifier | |
| ReviewLevel | Peer-reviewed dataset |
| DatasetOrigin | Original dataset |
| RepositorySupport | Unsupported dataset by repository |
| PrimarySubmitter | Karima Chaoui |
| SpeciesList | scientific name: Homo sapiens (Human); NCBI TaxID: NEWT:9606; |
| ModificationList | acetylated residue; monohydroxylated residue; iodoacetamide derivatized residue |
| Instrument | Q Exactive |
Dataset History
| Revision | Datetime | Status | ChangeLog Entry |
|---|
| 0 | 2021-10-21 05:06:14 | ID requested | |
| ⏵ 1 | 2026-01-30 04:23:08 | announced | |
Publication List
Keyword List
| submitter keyword: obesity, adipocyte,hormone-sensitive lipase, extracellular matrix |
Contact List
| Odile Schiltz |
|---|
| contact affiliation | Institut de Pharmacologie et de Biologie Structurale, IPBS, Université de Toulouse, CNRS, UPS, Toulouse, France. |
| contact email | Odile.Schiltz@ipbs.fr |
| lab head | |
| Karima Chaoui |
|---|
| contact affiliation | IPBS/CNRS |
| contact email | karima.chaoui@ipbs.fr |
| dataset submitter | |
Full Dataset Link List
Dataset FTP location
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| PRIDE project URI |
Repository Record List
[ + ]
[ - ]
- PRIDE
- PXD029261
- Label: PRIDE project
- Name: Impact of hormone-sensitive lipase depletion on adipocyte secretome
