PXD029258

PXD029258 is an original dataset announced via ProteomeXchange.

Title	PHF20 and PHF20L1 in NSL complex
Description	The methyl lysine readers PHF (plant homeodomain finger) 20 (PHF20) and its homolog PHF20 Like 1 (PHF20L1) are known components of the NSL (non-specific lethal) complex that regulates gene expression through its histone acetyltransferase activity. In the current model, both PHF homologs coexist in the same NSL complex although this was not formally tested; nor have the functions of PHF20 and PHF20L1 regarding NSL complex integrity and transcriptional regulation been investigated. By performing an in-depth biochemical and functional characterization, we define the association and contributions of the two methyl lysine reader homologs PHF20 and PHF20L1 to the NSL complex.
HostingRepository	PRIDE
AnnounceDate	2022-05-27
AnnouncementXML	Submission_2022-05-27_05:23:06.235.xml
DigitalObjectIdentifier	https://dx.doi.org/10.6019/PXD029258
ReviewLevel	Peer-reviewed dataset
DatasetOrigin	Original dataset
RepositorySupport	Supported dataset by repository
PrimarySubmitter	Margarida Almeida Santos
SpeciesList	scientific name: Homo sapiens (Human); NCBI TaxID: 9606;
ModificationList	monohydroxylated residue; iodoacetamide derivatized residue; deamidated residue
Instrument	Orbitrap Fusion

Revision	Datetime	Status	ChangeLog Entry
0	2021-10-20 23:16:28	ID requested
⏵ 1	2022-05-27 05:23:07	announced

Van HT, Harkins PR, Patel A, Jain AK, Lu Y, Bedford MT, Santos MA, gene expression-regulating NSL complexes. J Biol Chem, 298(3):101588(2022) [pubmed]

submitter keyword: PHF20, PHF20L1, U2OS, AP-MS

Margarida A. Santos
contact affiliation	Department of Epigenetics and Molecular Carcinogenesis, The University of Texas MD Anderson Cancer Center, Houston, TX, 77030, USA.
contact email	mialmeidasantos@mdanderson.org
lab head
Margarida Almeida Santos
contact affiliation	UT MD Anderson Cancer Center
contact email	mialmeidasantos@mdanderson.org
dataset submitter

Dataset FTP location NOTE: Most web browsers have now discontinued native support for FTP access within the browser window. But you can usually install another FTP app (we recommend FileZilla) and configure your browser to launch the external application when you click on this FTP link. Or otherwise, launch an app that supports FTP (like FileZilla) and use this address: ftp://ftp.pride.ebi.ac.uk/pride/data/archive/2022/04/PXD029258

PRIDE project URI

• PRIDE
  1. PXD029258
     1. Label: PRIDE project
     2. Name: PHF20 and PHF20L1 in NSL complex