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PXD029243

PXD029243 is an original dataset announced via ProteomeXchange.

Dataset Summary
TitleThe proteomic response of Clostridioides difficile to the Chlorotonil A derivative ChtB1-Epo2
DescriptionThe anaerobic, spore-forming pathogen Clostridioides difficile infects the gastrointestinal tract of higher mammals, including humans, and is the major causative agent of antibiotic-associated diarrhea. Moreover, recurrence and re-infection rates after a first successful antibiotic therapy are substantially high. To overcome the problem of recurrence and re-infection new antibiotics are urgently required that are more selective for the pathogen but spare other members of the microbiota. In turn, the microbial community inside the intestine is allowed to recover and to re-establish colonization resistance to protect against recurrence. The data presented here aim at analyzing the ability of the macrolide compound chlorotonil A to meet the requirements of C. difficile specific drug.
HostingRepositoryPRIDE
AnnounceDate2023-03-29
AnnouncementXMLSubmission_2023-03-29_03:14:05.820.xml
DigitalObjectIdentifier
ReviewLevelPeer-reviewed dataset
DatasetOriginOriginal dataset
RepositorySupportUnsupported dataset by repository
PrimarySubmitterDanielaZuehlke
SpeciesList scientific name: Peptoclostridium difficile (strain 630) (Clostridium difficile); NCBI TaxID: 272563;
ModificationListiodoacetamide derivatized residue
InstrumentQ Exactive HF
Dataset History
RevisionDatetimeStatusChangeLog Entry
02021-10-20 08:12:35ID requested
12023-03-29 03:14:06announced
Publication List
Dataset with its publication pending
Keyword List
submitter keyword: chlorotonil A, Clostridioides difficile, antibiotic resistance, antibiotic therapy, colonization resistance, selectivity
Contact List
SusanneSievers
contact affiliationUniversity of Greifswald, Institute of Microbiology, Department of Microbial Physiology and Molecular Biology
contact emailsieverss@uni-greifswald.de
lab head
DanielaZuehlke
contact affiliationUniversity of Greifswald, Institute of Microbiology
contact emailzuehlke@uni-greifswald.de
dataset submitter
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Dataset FTP location
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PRIDE project URI
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