PXD029243

PXD029243 is an original dataset announced via ProteomeXchange.

Title	The proteomic response of Clostridioides difficile to the Chlorotonil A derivative ChtB1-Epo2
Description	The anaerobic, spore-forming pathogen Clostridioides difficile infects the gastrointestinal tract of higher mammals, including humans, and is the major causative agent of antibiotic-associated diarrhea. Moreover, recurrence and re-infection rates after a first successful antibiotic therapy are substantially high. To overcome the problem of recurrence and re-infection new antibiotics are urgently required that are more selective for the pathogen but spare other members of the microbiota. In turn, the microbial community inside the intestine is allowed to recover and to re-establish colonization resistance to protect against recurrence. The data presented here aim at analyzing the ability of the macrolide compound chlorotonil A to meet the requirements of C. difficile specific drug.
HostingRepository	PRIDE
AnnounceDate	2023-03-29
AnnouncementXML	Submission_2023-03-29_03:14:05.820.xml
DigitalObjectIdentifier
ReviewLevel	Peer-reviewed dataset
DatasetOrigin	Original dataset
RepositorySupport	Unsupported dataset by repository
PrimarySubmitter	DanielaZuehlke
SpeciesList	scientific name: Peptoclostridium difficile (strain 630) (Clostridium difficile); NCBI TaxID: 272563;
ModificationList	iodoacetamide derivatized residue
Instrument	Q Exactive HF

Revision	Datetime	Status	ChangeLog Entry
0	2021-10-20 08:12:35	ID requested
⏵ 1	2023-03-29 03:14:06	announced

Dataset with its publication pending

submitter keyword: chlorotonil A, Clostridioides difficile, antibiotic resistance, antibiotic therapy, colonization resistance, selectivity

SusanneSievers
contact affiliation	University of Greifswald, Institute of Microbiology, Department of Microbial Physiology and Molecular Biology
contact email	sieverss@uni-greifswald.de
lab head
DanielaZuehlke
contact affiliation	University of Greifswald, Institute of Microbiology
contact email	zuehlke@uni-greifswald.de
dataset submitter

Dataset FTP location NOTE: Most web browsers have now discontinued native support for FTP access within the browser window. But you can usually install another FTP app (we recommend FileZilla) and configure your browser to launch the external application when you click on this FTP link. Or otherwise, launch an app that supports FTP (like FileZilla) and use this address: ftp://ftp.pride.ebi.ac.uk/pride/data/archive/2023/03/PXD029243

PRIDE project URI

• PRIDE
  1. PXD029243
     1. Label: PRIDE project
     2. Name: The proteomic response of Clostridioides difficile to the Chlorotonil A derivative ChtB1-Epo2