PXD029243 is an
original dataset announced via ProteomeXchange.
Dataset Summary
Title | The proteomic response of Clostridioides difficile to the Chlorotonil A derivative ChtB1-Epo2 |
Description | The anaerobic, spore-forming pathogen Clostridioides difficile infects the gastrointestinal tract of higher mammals, including humans, and is the major causative agent of antibiotic-associated diarrhea. Moreover, recurrence and re-infection rates after a first successful antibiotic therapy are substantially high. To overcome the problem of recurrence and re-infection new antibiotics are urgently required that are more selective for the pathogen but spare other members of the microbiota. In turn, the microbial community inside the intestine is allowed to recover and to re-establish colonization resistance to protect against recurrence. The data presented here aim at analyzing the ability of the macrolide compound chlorotonil A to meet the requirements of C. difficile specific drug. |
HostingRepository | PRIDE |
AnnounceDate | 2023-03-29 |
AnnouncementXML | Submission_2023-03-29_03:14:05.820.xml |
DigitalObjectIdentifier | |
ReviewLevel | Peer-reviewed dataset |
DatasetOrigin | Original dataset |
RepositorySupport | Unsupported dataset by repository |
PrimarySubmitter | DanielaZuehlke |
SpeciesList | scientific name: Peptoclostridium difficile (strain 630) (Clostridium difficile); NCBI TaxID: 272563; |
ModificationList | iodoacetamide derivatized residue |
Instrument | Q Exactive HF |
Dataset History
Revision | Datetime | Status | ChangeLog Entry |
0 | 2021-10-20 08:12:35 | ID requested | |
⏵ 1 | 2023-03-29 03:14:06 | announced | |
Publication List
Dataset with its publication pending |
Keyword List
submitter keyword: chlorotonil A, Clostridioides difficile, antibiotic resistance, antibiotic therapy, colonization resistance, selectivity |
Contact List
SusanneSievers |
contact affiliation | University of Greifswald, Institute of Microbiology, Department of Microbial Physiology and Molecular Biology |
contact email | sieverss@uni-greifswald.de |
lab head | |
DanielaZuehlke |
contact affiliation | University of Greifswald, Institute of Microbiology |
contact email | zuehlke@uni-greifswald.de |
dataset submitter | |
Full Dataset Link List
Dataset FTP location
NOTE: Most web browsers have now discontinued native support for FTP access within the browser window. But you can usually install another FTP app (we recommend FileZilla) and configure your browser to launch the external application when you click on this FTP link. Or otherwise, launch an app that supports FTP (like FileZilla) and use this address: ftp://ftp.pride.ebi.ac.uk/pride/data/archive/2023/03/PXD029243 |
PRIDE project URI |
Repository Record List
[ + ]
[ - ]
- PRIDE
- PXD029243
- Label: PRIDE project
- Name: The proteomic response of Clostridioides difficile to the Chlorotonil A derivative ChtB1-Epo2