PXD029147

PXD029147 is an original dataset announced via ProteomeXchange.

Title	A proteomic analysis reveals novel miRNA-200c targets and altered signaling pathways in the field of detoxification
Description	MircoRNAs are small RNAs which regulate a pleiotropy of cellular processes and are also involved in tumorigenesis, cancer progression and therapy resistance. We investigated the influence of miRNA-200c on chemoresistance of tumor cells. A proteomic approach identified glutathione S-transferases to be differentially expressed when miR-200c was knocked out and cells were treated with the chemotherapeutic drug doxorubicin.
HostingRepository	PRIDE
AnnounceDate	2023-11-14
AnnouncementXML	Submission_2023-11-14_07:40:32.167.xml
DigitalObjectIdentifier
ReviewLevel	Peer-reviewed dataset
DatasetOrigin	Original dataset
RepositorySupport	Unsupported dataset by repository
PrimarySubmitter	Jan Bernd Stöckl
SpeciesList	scientific name: Homo sapiens (Human); NCBI TaxID: 9606;
ModificationList	iodoacetamide derivatized residue
Instrument	Q Exactive HF-X

Revision	Datetime	Status	ChangeLog Entry
0	2021-10-15 06:20:17	ID requested
1	2023-03-10 15:09:24	announced
⏵ 2	2023-11-14 07:40:35	announced	2023-11-14: Updated project metadata.

K, ö, hler B, Dubovik S, H, ö, rterer E, Wilk U, St, ö, ckl JB, Tekarslan-Sahin H, Ljepoja B, Paulitschke P, Fr, ö, hlich T, Wagner E, Roidl A, Combating Drug Resistance by Exploiting miRNA-200c-Controlled Phase II Detoxification. Cancers (Basel), 14(22):(2022) [pubmed]

submitter keyword: miR-200c, microRNA, glutathione S-transferase,cancer, chemotherapy

Thomas Fröhlich
contact affiliation	Ludwig-Maximilians-Universität München Genzentrum Laboratory for Functional Genome Analysis Feodor-Lynen-Str. 25 D-81377 München
contact email	frohlich@genzentrum.lmu.de
lab head
Jan Bernd Stöckl
contact affiliation	Genzentrum der LMU München
contact email	stoeckl@genzentrum.lmu.de
dataset submitter

Dataset FTP location NOTE: Most web browsers have now discontinued native support for FTP access within the browser window. But you can usually install another FTP app (we recommend FileZilla) and configure your browser to launch the external application when you click on this FTP link. Or otherwise, launch an app that supports FTP (like FileZilla) and use this address: ftp://ftp.pride.ebi.ac.uk/pride/data/archive/2023/03/PXD029147

PRIDE project URI

• PRIDE
  1. PXD029147
     1. Label: PRIDE project
     2. Name: A proteomic analysis reveals novel miRNA-200c targets and altered signaling pathways in the field of detoxification