PXD029116

PXD029116 is an original dataset announced via ProteomeXchange.

Title	Articular cartilage proteome differentiates by zones during osteoarthritis
Description	Articular cartilage is deprived of blood vessels and nerves, and the only cells residing in this tissue are chondrocytes. The molecular properties of the articular cartilage and the architecture of the extracellular matrix demonstrate a complex structure that differentiates on the depth of tissue. Osteoarthritis (OA) is a degenerative joint disease, the most common form of arthritis, affecting the whole joint. It is associated with ageing and affects the joints that have been continually stressed throughout life including the knees, hips, fingers, and lower spine region. OA is a multifactorial condition of joint characterised by articular cartilage loss, subchondral bone sclerosis, and inflammation leading to progressive joint degradation, structural alterations, loss of mobility and pain. Articular cartilage biology is well studied with a focus on musculoskeletal diseases and cartilage development. However, there are relatively few studies focusing on zonal changes in the cartilage during osteoarthritis.
HostingRepository	PRIDE
AnnounceDate	2022-05-19
AnnouncementXML	Submission_2022-05-19_07:03:02.152.xml
DigitalObjectIdentifier	https://dx.doi.org/10.6019/PXD029116
ReviewLevel	Peer-reviewed dataset
DatasetOrigin	Original dataset
RepositorySupport	Supported dataset by repository
PrimarySubmitter	Yalda Ashraf Kharaz
SpeciesList	scientific name: Homo sapiens (Human); NCBI TaxID: 9606;
ModificationList	monohydroxylated residue; iodoacetamide derivatized residue
Instrument	Q Exactive

Revision	Datetime	Status	ChangeLog Entry
0	2021-10-13 22:40:16	ID requested
⏵ 1	2022-05-19 07:03:02	announced

Shorter E, Avelar R, Zachariou M, Spyrou GM, Raina P, Smagul A, Ashraf Kharaz Y, Peffers M, Goljanek-Whysall K, de Magalh, ã, es JP, Poulet B, Identifying Novel Osteoarthritis-Associated Genes in Human Cartilage Using a Systematic Meta-Analysis and a Multi-Source Integrated Network. Int J Mol Sci, 23(8):(2022) [pubmed]

submitter keyword: Osteoarthritis, zonal changes and ageing

Mandy Peffers
contact affiliation	Musculoskeletal and Ageing Science Research Lead, Institute of Life Course and Medical Sciences, Faculty of Health & Life Sciences, University of Liverpool
contact email	peffs@liverpool.ac.uk
lab head
Yalda Ashraf Kharaz
contact affiliation	University of Liverpool
contact email	yalda@liverpool.ac.uk
dataset submitter

Dataset FTP location NOTE: Most web browsers have now discontinued native support for FTP access within the browser window. But you can usually install another FTP app (we recommend FileZilla) and configure your browser to launch the external application when you click on this FTP link. Or otherwise, launch an app that supports FTP (like FileZilla) and use this address: ftp://ftp.pride.ebi.ac.uk/pride/data/archive/2022/05/PXD029116

PRIDE project URI

• PRIDE
  1. PXD029116
     1. Label: PRIDE project
     2. Name: Articular cartilage proteome differentiates by zones during osteoarthritis