PXD029071

PXD029071 is an original dataset announced via ProteomeXchange.

Title	Transglutaminase 3 crosslinks MUC2 and stabilizes the colonic mucus layer
Description	Mucus/MUC2 from TGM3-deficient mice is less cross-linked with isopeptide-bond cross-links compared to Mucus/MUC2 from WT mice. This results in protease-labile MUC2-molecules that become degraded in the colonic lumen
HostingRepository	PRIDE
AnnounceDate	2023-04-11
AnnouncementXML	Submission_2023-04-11_06:34:34.759.xml
DigitalObjectIdentifier
ReviewLevel	Peer-reviewed dataset
DatasetOrigin	Original dataset
RepositorySupport	Unsupported dataset by repository
PrimarySubmitter	ChristianRecktenwald
SpeciesList	scientific name: Mus musculus (Mouse); NCBI TaxID: 10090;
ModificationList	monohydroxylated residue; iodoacetamide derivatized residue
Instrument	Q Exactive HF

Revision	Datetime	Status	ChangeLog Entry
0	2021-10-12 03:22:37	ID requested
1	2022-02-09 07:52:01	announced
⏵ 2	2023-04-11 06:34:36	announced	2023-04-11: Updated project metadata.

Sharpen JDA, Dolan B, Nystr, ö, m EEL, Birchenough GMH, Arike L, Martinez-Abad B, Johansson MEV, Hansson GC, Recktenwald CV, Transglutaminase 3 crosslinks the secreted gel-forming mucus component Mucin-2 and stabilizes the colonic mucus layer. Nat Commun, 13(1):45(2022) [pubmed]

submitter keyword: MUC2, transglutaminase,Mucus

Gunnar ClaesHansson
contact affiliation	University of Gothenburg Institute of Biomedicine Department of Medical Biochemistry Mucin Biology Groups Sweden
contact email	gunnar.hansson@medkem.gu.se
lab head
ChristianRecktenwald
contact affiliation	Department of Medical Biochemistry University of Gothenburg
contact email	christian.recktenwald@medkem.gu.se
dataset submitter

Dataset FTP location NOTE: Most web browsers have now discontinued native support for FTP access within the browser window. But you can usually install another FTP app (we recommend FileZilla) and configure your browser to launch the external application when you click on this FTP link. Or otherwise, launch an app that supports FTP (like FileZilla) and use this address: ftp://ftp.pride.ebi.ac.uk/pride/data/archive/2022/02/PXD029071

PRIDE project URI

• PRIDE
  1. PXD029071
     1. Label: PRIDE project
     2. Name: Transglutaminase 3 crosslinks MUC2 and stabilizes the colonic mucus layer