PXD028953

PXD028953 is an original dataset announced via ProteomeXchange.

Title	Proteomics of extracellular matrix from eIF4E deficient mouse mammary fat pad
Description	It was demonstrated that mice with eIF4E that cannot be activated by phosphorylation (S209A) produced extracellular matrix (ECM) less conducive to breast cancer tumor invasion and metastasis. To examine whether this could in part bedue to differences in the protein composition we analyzed the proteome of soluble and insoluble ECM fractions derived from the mammary fat pad of mice with either WT or constitutively inactivated (S209A or "KI") eIF4E.
HostingRepository	PRIDE
AnnounceDate	2022-08-12
AnnouncementXML	Submission_2022-08-11_23:54:44.476.xml
DigitalObjectIdentifier
ReviewLevel	Peer-reviewed dataset
DatasetOrigin	Original dataset
RepositorySupport	Unsupported dataset by repository
PrimarySubmitter	Vincent Richard
SpeciesList	scientific name: Mus musculus (Mouse); NCBI TaxID: 10090;
ModificationList	iodoacetamide derivatized residue
Instrument	Q Exactive Plus

Revision	Datetime	Status	ChangeLog Entry
0	2021-10-05 08:09:14	ID requested
⏵ 1	2022-08-11 23:54:45	announced

Preston SEJ, Bartish M, Richard VR, Aghigh A, Gon, ç, alves C, Smith-Voudouris J, Huang F, Th, é, bault P, Cleret-Buhot A, Lapointe R, L, é, gar, é F, Postovit LM, Zahedi RP, Borchers CH, Miller WH, Del Rinc, ó, n SV, Phosphorylation of eIF4E in the stroma drives the production and spatial organisation of collagen type I in the mammary gland. Matrix Biol, 111():264-288(2022) [pubmed]

submitter keyword: Mouse, mammary fat pad, extracellular matrix, proteome, breast cancer, eIF4E

Christoph H. Borchers
contact affiliation	Segal Cancer Proteomics Centre, Lady Davis Institute, Jewish General Hospital, McGill University, Montreal, Quebec, Canada
contact email	christoph.borchers@mcgill.ca
lab head
Vincent Richard
contact affiliation	Lady Davis Institute for Medical Research, Jewish General Hospital, McGill University
contact email	vincentroyrichard@gmail.com
dataset submitter

Dataset FTP location NOTE: Most web browsers have now discontinued native support for FTP access within the browser window. But you can usually install another FTP app (we recommend FileZilla) and configure your browser to launch the external application when you click on this FTP link. Or otherwise, launch an app that supports FTP (like FileZilla) and use this address: ftp://ftp.pride.ebi.ac.uk/pride/data/archive/2022/08/PXD028953

PRIDE project URI

• PRIDE
  1. PXD028953
     1. Label: PRIDE project
     2. Name: Proteomics of extracellular matrix from eIF4E deficient mouse mammary fat pad