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PXD028944

PXD028944 is an original dataset announced via ProteomeXchange.

Dataset Summary
TitleCirculating Microvesicles and Exosomes in Small Cell Lung Cancer by Quantitative Proteomics
DescriptionEarly detection of small cell lung cancer crucially demands highly reliable markers. Growing evidence suggests that extracellular vesicles carry tumor cell-specific cargo suitable as protein markers in cancer. Therefore, we isolated plasma-derived microvesicles from newly diagnosed small cell lung cancer patients and investigated proteome dynamics of these microvesicles aiming at improving the detection of small cell lung cancer. A total of 1,223 proteins were initially identified. After data processing and statistical analysis, several proteins were found to be differentially expressed in comparing small cell lung cancer patients and healthy individuals. Furthermore, our data may indicate involvement of complement activation, integrin-mediated signaling, cell adhesion- and migration, and blood coagulation in small cell lung cancer pathogenesis.
HostingRepositoryPRIDE
AnnounceDate2022-05-27
AnnouncementXMLSubmission_2022-05-27_05:13:39.419.xml
DigitalObjectIdentifier
ReviewLevelPeer-reviewed dataset
DatasetOriginOriginal dataset
RepositorySupportUnsupported dataset by repository
PrimarySubmitterBent Honoré
SpeciesList scientific name: Homo sapiens (Human); NCBI TaxID: 9606;
ModificationListNo PTMs are included in the dataset
InstrumentOrbitrap Fusion
Dataset History
RevisionDatetimeStatusChangeLog Entry
02021-10-05 02:00:24ID requested
12022-05-27 05:13:40announced
Publication List
Pedersen S, Jensen KP, Honor, é B, Kristensen SR, Pedersen CH, Szejniuk WM, Maltesen RG, Falkmer U, Circulating microvesicles and exosomes in small cell lung cancer by quantitative proteomics. Clin Proteomics, 19(1):2(2022) [pubmed]
Keyword List
submitter keyword: Human, Plasma, Extracellular vesicles, LC-MS/MS
Contact List
Bent Honoré
contact affiliationAarhus University
contact emailbh@biomed.au.dk
lab head
Bent Honoré
contact affiliationAarhus University
contact emailbent.honore@dadlnet.dk
dataset submitter
Full Dataset Link List
Dataset FTP location
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PRIDE project URI
Repository Record List
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