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PXD028917

PXD028917 is an original dataset announced via ProteomeXchange.

Dataset Summary
TitleMouse sperm protamine mass spectrometry
DescriptionConventional dogma presumes that protamine-mediated DNA compaction in sperm is achieved by passive electrostatics between DNA and the arginine-rich core of protamines. However, phylogenetic analysis reveals several non-arginine residues that are conserved within, but not across, species. The functional significance of these residues or post-translational modifications are poorly understood. In this experiment, we investigated the presence of post-translational modifications on mouse protamine 1 to begin to dissect their function in vivo.
HostingRepositoryPRIDE
AnnounceDate2023-05-17
AnnouncementXMLSubmission_2023-05-17_12:22:52.511.xml
DigitalObjectIdentifierhttps://dx.doi.org/10.6019/PXD028917
ReviewLevelPeer-reviewed dataset
DatasetOriginOriginal dataset
RepositorySupportSupported dataset by repository
PrimarySubmitterLindsayMoritz
SpeciesList scientific name: Mus musculus (Mouse); NCBI TaxID: 10090;
ModificationListmonomethylated residue; phosphorylated residue; acetylated residue; iodoacetamide derivatized residue
InstrumentQ Exactive
Dataset History
RevisionDatetimeStatusChangeLog Entry
02021-10-04 10:00:35ID requested
12023-05-17 12:22:52announced
Publication List
10.6019/PXD028917;
Keyword List
submitter keyword: sperm,protamine, chromatin
Contact List
SueHammoud
contact affiliationDepartment of Human Genetics, University of Michigan, USA
contact emailhammou@med.umich.edu
lab head
LindsayMoritz
contact affiliationUniversity of Michigan
contact emailmoritzle@umich.edu
dataset submitter
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Dataset FTP location
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