PXD028916

PXD028916 is an original dataset announced via ProteomeXchange.

Title	Quantitative proteomic analysis of bronchoalveolar lavage fluid in West Highland white terriers with canine idiopathic pulmonary fibrosis C4PR_LIV
Description	Canine idiopathic pulmonary fibrosis (CIPF) is a chronic, progressive, interstitial fibrosing lung disease, manifesting as cough, exercise intolerance and ultimately, dyspnea and respiratory failure. It mainly affects West Highland white terriers (WHWTs), lacks curable treatment and has a poor prognosis. Aspiration of gastroesophageal refluxate may play a role in the development of CIPF. In the first part of this study, we completed label-free quantitative proteomic analysis of bronchoalveolar lavage fluid (BALF) from CIPF and healthy WHWTs. In the second part, we evaluated potential protein markers of reflux aspiration from canine gastric juice and vomitus and evaluated whether these were present in BALF from the two groups.
HostingRepository	PRIDE
AnnounceDate	2022-05-20
AnnouncementXML	Submission_2022-05-19_21:48:17.157.xml
DigitalObjectIdentifier	https://dx.doi.org/10.6019/PXD028916
ReviewLevel	Peer-reviewed dataset
DatasetOrigin	Original dataset
RepositorySupport	Supported dataset by repository
PrimarySubmitter	Rosemary Maher
SpeciesList	scientific name: Canis lupus familiaris; NCBI TaxID: 9615;
ModificationList	monohydroxylated residue; iodoacetamide derivatized residue
Instrument	Q Exactive HF

Revision	Datetime	Status	ChangeLog Entry
0	2021-10-04 10:00:16	ID requested
⏵ 1	2022-05-19 21:48:17	announced

Maher RE, M, ä, ä, tt, ä M, Beynon RJ, Laurila HP, McNamara PS, Rajam, ä, ki MM, Quantitative proteomic analysis of bronchoalveolar lavage fluid in West Highland white terriers with canine idiopathic pulmonary fibrosis. BMC Vet Res, 18(1):121(2022) [pubmed]

submitter keyword: Bronchoalveolar lavage fluid

Canine

Reflux aspiration

Proteomics: West Highland white terrier

Robert John Beynon
contact affiliation	Centre for Proteome Research, University of Liverpool
contact email	rbeynon@liverpool.ac.uk
lab head
Rosemary Maher
contact affiliation	University of Liverpool
contact email	rem@liverpool.ac.uk
dataset submitter

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PRIDE project URI

• PRIDE
  1. PXD028916
     1. Label: PRIDE project
     2. Name: Quantitative proteomic analysis of bronchoalveolar lavage fluid in West Highland white terriers with canine idiopathic pulmonary fibrosis C4PR_LIV