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PXD028832

PXD028832 is an original dataset announced via ProteomeXchange.

Dataset Summary
TitleThe METTL5-TRMT112 N6-methyladenosine methyltransferase complex regulates metabolism and development via translation (Identification of m1A mRNA methyltransferase in nucleus by TMT11-LC-MS/MS)
Descriptionm1A has long been known to be important in tRNA and rRNA, but we recently mapped many m1A sites in mRNA as well. m1A is found on the 5’ ends of genes, usually around the first splice site, but we have yet to understand how it effects transcript fate. Identifying the methyltransferase would be a major first step towards understanding m1A function.
HostingRepositoryPRIDE
AnnounceDate2021-11-30
AnnouncementXMLSubmission_2021-11-30_14:44:34.687.xml
DigitalObjectIdentifier
ReviewLevelPeer-reviewed dataset
DatasetOriginOriginal dataset
RepositorySupportUnsupported dataset by repository
PrimarySubmitterZuo-Fei Yuan
SpeciesList scientific name: Homo sapiens (Human); NCBI TaxID: 9606;
ModificationListmonohydroxylated residue
InstrumentQ Exactive HF
Dataset History
RevisionDatetimeStatusChangeLog Entry
02021-09-29 01:33:37ID requested
12021-11-30 14:44:35announced
Publication List
Dataset with its publication pending
Keyword List
submitter keyword: Proteomics, m1A mRNA methyltransferase, METTL5, TRMT112, mass spectrometry
Contact List
Haiyan Tan
contact affiliationCenter for Proteomics and Metabolomics St. Jude Children's Research Hospital
contact emailHaiyan.Tan@stjude.org
lab head
Zuo-Fei Yuan
contact affiliationSt. Jude Children's Research Hospital
contact emailzuo-fei.yuan@stjude.org
dataset submitter
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Dataset FTP location
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