PXD028832

PXD028832 is an original dataset announced via ProteomeXchange.

Title	The METTL5-TRMT112 N6-methyladenosine methyltransferase complex regulates metabolism and development via translation (Identification of m1A mRNA methyltransferase in nucleus by TMT11-LC-MS/MS)
Description	m1A has long been known to be important in tRNA and rRNA, but we recently mapped many m1A sites in mRNA as well. m1A is found on the 5’ ends of genes, usually around the first splice site, but we have yet to understand how it effects transcript fate. Identifying the methyltransferase would be a major first step towards understanding m1A function.
HostingRepository	PRIDE
AnnounceDate	2021-11-30
AnnouncementXML	Submission_2021-11-30_14:44:34.687.xml
DigitalObjectIdentifier
ReviewLevel	Peer-reviewed dataset
DatasetOrigin	Original dataset
RepositorySupport	Unsupported dataset by repository
PrimarySubmitter	Zuo-Fei Yuan
SpeciesList	scientific name: Homo sapiens (Human); NCBI TaxID: 9606;
ModificationList	monohydroxylated residue
Instrument	Q Exactive HF

Revision	Datetime	Status	ChangeLog Entry
0	2021-09-29 01:33:37	ID requested
⏵ 1	2021-11-30 14:44:35	announced

Dataset with its publication pending

submitter keyword: Proteomics, m1A mRNA methyltransferase, METTL5, TRMT112, mass spectrometry

Haiyan Tan
contact affiliation	Center for Proteomics and Metabolomics St. Jude Children's Research Hospital
contact email	Haiyan.Tan@stjude.org
lab head
Zuo-Fei Yuan
contact affiliation	St. Jude Children's Research Hospital
contact email	zuo-fei.yuan@stjude.org
dataset submitter

Dataset FTP location NOTE: Most web browsers have now discontinued native support for FTP access within the browser window. But you can usually install another FTP app (we recommend FileZilla) and configure your browser to launch the external application when you click on this FTP link. Or otherwise, launch an app that supports FTP (like FileZilla) and use this address: ftp://ftp.pride.ebi.ac.uk/pride/data/archive/2021/11/PXD028832

PRIDE project URI

• PRIDE
  1. PXD028832
     1. Label: PRIDE project
     2. Name: The METTL5-TRMT112 N6-methyladenosine methyltransferase complex regulates metabolism and development via translation (Identification of m1A mRNA methyltransferase in nucleus by TMT11-LC-MS/MS)