PXD028822 is an
original dataset announced via ProteomeXchange.
Dataset Summary
| Title | Proteomic Analysis of Canine Hepatobiliary Neuroendocrine Neoplasms |
| Description | Neuroendocrine neoplasms of the gallbladder and liver occur rarely in dogs and humans. A recent reclassification of human neuroendocrine neoplasms by the World Health Organization has refined categorization of these tumors by morphology, replicative indices, and molecular signatures. In humans, these factors correlate with survival outcomes. Improved characterization of these tumors is needed in dogs to identify diagnostic biomarkers and determine therapeutic strategies. To achieve this objective, the proteome of 3 canine hepatobiliary neoplasms was compared to normal canine adrenal and liver tissue from formalin-fixed paraffin-embedded samples. Thirty-two upregulated and 121 downregulated differentially expressed proteins were identified in the hepatobiliary neuroendocrine neoplasm samples. Among the upregulated proteins is galectin-1, a multivalent carbohydrate binding protein known to play a role in lung and pancreatic neuroendocrine neoplasia development and progression in humans. Drugs targeting the galectin family have shown promise as anticancer therapeutics in cervical cancer, prostate cancer, lung and pancreatic neuroendocrine neoplasia in human medicine. Galectin-1 may represent a novel treatment target in hepatobiliary neuroendocrine neoplasia in both humans and dogs. |
| HostingRepository | PRIDE |
| AnnounceDate | 2023-11-14 |
| AnnouncementXML | Submission_2023-11-14_08:28:59.908.xml |
| DigitalObjectIdentifier | https://dx.doi.org/10.6019/PXD028822 |
| ReviewLevel | Peer-reviewed dataset |
| DatasetOrigin | Original dataset |
| RepositorySupport | Supported dataset by repository |
| PrimarySubmitter | Stephanie Byrum |
| SpeciesList | scientific name: Canis familiaris (Dog) (Canis lupus familiaris); NCBI TaxID: 9615; |
| ModificationList | monohydroxylated residue; iodoacetamide derivatized residue |
| Instrument | Orbitrap Eclipse |
Dataset History
| Revision | Datetime | Status | ChangeLog Entry |
|---|
| 0 | 2021-09-28 23:02:58 | ID requested | |
| 1 | 2023-03-10 19:17:47 | announced | |
| ⏵ 2 | 2023-11-14 08:29:03 | announced | 2023-11-14: Updated project metadata. |
Publication List
| 10.6019/PXD028822; |
| Batts TL, Sasaki E, Miller M, Sparago J, Bauer RW, Paulsen D, Boudreaux B, Liu CC, Byrum SD, Johnston AN, Neoplastic signatures: Comparative proteomics of canine hepatobiliary neuroendocrine tumors to normal niche tissue. PLoS One, 18(1):e0280928(2023) [pubmed] |
Keyword List
| submitter keyword: Neurouro |
Contact List
| Andrea Johnston |
|---|
| contact affiliation | Veterinary Clinical Sciences, Louisiana State University School of Veterinary Medicine, Baton Rouge, Louisiana 70803 |
| contact email | johnston1@lsu.edu |
| lab head | |
| Stephanie Byrum |
|---|
| contact affiliation | UAMS |
| contact email | sbyrum@uams.edu |
| dataset submitter | |
Full Dataset Link List
Dataset FTP location
NOTE: Most web browsers have now discontinued native support for FTP access within the browser window. But you can usually install another FTP app (we recommend FileZilla) and configure your browser to launch the external application when you click on this FTP link. Or otherwise, launch an app that supports FTP (like FileZilla) and use this address: ftp://ftp.pride.ebi.ac.uk/pride/data/archive/2023/03/PXD028822 |
| PRIDE project URI |
Repository Record List
[ + ]
[ - ]
- PRIDE
- PXD028822
- Label: PRIDE project
- Name: Proteomic Analysis of Canine Hepatobiliary Neuroendocrine Neoplasms
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