PXD028816

PXD028816 is an original dataset announced via ProteomeXchange.

Title	Fluoxetine triggers synaptic vesicle exo/endocytosis, mitochondrial energy metabolism and dynamics in hippocampus of socially isolated rats
Description	We used comparative proteomic approach to identify proteome changes in purified synaptic terminals (synaptosomes) of rats exposed to chronic social isolation (CSIS) (6 weeks), animal model for depression, followed by chronic Fluoxetine treatment (last 3 weeks of CSIS) (therapeutic effect). Our aim was to examine a subcellular compartment enriched in proteins involved in synaptic function.
HostingRepository	PRIDE
AnnounceDate	2023-11-14
AnnouncementXML	Submission_2023-11-14_08:28:58.147.xml
DigitalObjectIdentifier
ReviewLevel	Peer-reviewed dataset
DatasetOrigin	Original dataset
RepositorySupport	Unsupported dataset by repository
PrimarySubmitter	Victor Costina
SpeciesList	scientific name: Rattus norvegicus (Rat); NCBI TaxID: 10116;
ModificationList	S-carboxamidoethyl-L-cysteine; phosphorylated residue; acetylated residue; monohydroxylated residue; iodoacetamide derivatized residue
Instrument	LTQ Orbitrap

Revision	Datetime	Status	ChangeLog Entry
0	2021-09-28 09:41:48	ID requested
1	2023-03-10 19:13:06	announced
⏵ 2	2023-11-14 08:29:00	announced	2023-11-14: Updated project metadata.

Filipovi, ć D, Costina V, Findeisen P, Inta D, Fluoxetine Enhances Synaptic Vesicle Trafficking and Energy Metabolism in the Hippocampus of Socially Isolated Rats. Int J Mol Sci, 23(23):(2022) [pubmed]

submitter keyword: proteomics, rat, LC-MS,Hippocampus

Peter Findeisen
contact affiliation	Medical Faculty Mannheim, Institute for Clinical Chemistry
contact email	Peter.Findeisen@medma.uni-heidelberg.de
lab head
Victor Costina
contact affiliation	Institute for Clinical Chemistry, Medical Faculty Mannheim of the University of Heidelberg
contact email	Victor.Costina@medma.uni-heidelberg.de
dataset submitter

Dataset FTP location NOTE: Most web browsers have now discontinued native support for FTP access within the browser window. But you can usually install another FTP app (we recommend FileZilla) and configure your browser to launch the external application when you click on this FTP link. Or otherwise, launch an app that supports FTP (like FileZilla) and use this address: ftp://ftp.pride.ebi.ac.uk/pride/data/archive/2023/03/PXD028816

PRIDE project URI

• PRIDE
  1. PXD028816
     1. Label: PRIDE project
     2. Name: Fluoxetine triggers synaptic vesicle exo/endocytosis, mitochondrial energy metabolism and dynamics in hippocampus of socially isolated rats