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PXD028733

PXD028733 is an original dataset announced via ProteomeXchange.

Dataset Summary
TitleA whole genome CRISPR screen identifies AHR loss as a mechanism of resistance to a PARP7 inhibitor
DescriptionInhibitors directed towards PARP1 and PARP2 are approved agents for the treatment of BRCA-related cancers. Other members of the PARP family have also been implicated in cancer and are being assessed as therapeutic targets in cancer and other diseases. In fact, an inhibitor of PARP7 (RBN-2397) has now reached early-stage human clinical trials. Here, we performed a genome-wide CRISPR screen for genes that modify the response of cells to RBN-2397. We identify the polycyclic aromatic hydrocarbon receptor AHR and multiple components of the cohesin complex as determinants of resistance to this agent. Activators and inhibitors of AHR modulate the cellular response to PARP7 inhibition, suggesting potential combination therapy approaches.
HostingRepositoryPRIDE
AnnounceDate2022-04-06
AnnouncementXMLSubmission_2022-05-06_07:03:40.542.xml
DigitalObjectIdentifier
ReviewLevelPeer-reviewed dataset
DatasetOriginOriginal dataset
RepositorySupportUnsupported dataset by repository
PrimarySubmitterMinkyu Kim
SpeciesList scientific name: Homo sapiens (Human); NCBI TaxID: 9606;
ModificationListNo PTMs are included in the dataset
InstrumentQ Exactive
Dataset History
RevisionDatetimeStatusChangeLog Entry
02021-09-23 22:55:35ID requested
12022-04-06 09:12:27announced
22022-05-06 07:03:41announced2022-05-06: Updated publication reference for PubMed record(s): 35439318.
Publication List
Keyword List
submitter keyword: Human, PARP7, TurboID
Contact List
Nevan Krogan
contact affiliationUniversity of California San Francisco
contact emailminkyu.kim@ucsf.edu
lab head
Minkyu Kim
contact affiliationUniversity of California San Francisco
contact emailminkyu.kim@ucsf.edu
dataset submitter
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Dataset FTP location
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PRIDE project URI
Repository Record List
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