PXD028733 is an
original dataset announced via ProteomeXchange.
Dataset Summary
Title | A whole genome CRISPR screen identifies AHR loss as a mechanism of resistance to a PARP7 inhibitor |
Description | Inhibitors directed towards PARP1 and PARP2 are approved agents for the treatment of BRCA-related cancers. Other members of the PARP family have also been implicated in cancer and are being assessed as therapeutic targets in cancer and other diseases. In fact, an inhibitor of PARP7 (RBN-2397) has now reached early-stage human clinical trials. Here, we performed a genome-wide CRISPR screen for genes that modify the response of cells to RBN-2397. We identify the polycyclic aromatic hydrocarbon receptor AHR and multiple components of the cohesin complex as determinants of resistance to this agent. Activators and inhibitors of AHR modulate the cellular response to PARP7 inhibition, suggesting potential combination therapy approaches. |
HostingRepository | PRIDE |
AnnounceDate | 2022-04-06 |
AnnouncementXML | Submission_2022-05-06_07:03:40.542.xml |
DigitalObjectIdentifier | |
ReviewLevel | Peer-reviewed dataset |
DatasetOrigin | Original dataset |
RepositorySupport | Unsupported dataset by repository |
PrimarySubmitter | Minkyu Kim |
SpeciesList | scientific name: Homo sapiens (Human); NCBI TaxID: 9606; |
ModificationList | No PTMs are included in the dataset |
Instrument | Q Exactive |
Dataset History
Revision | Datetime | Status | ChangeLog Entry |
0 | 2021-09-23 22:55:35 | ID requested | |
1 | 2022-04-06 09:12:27 | announced | |
⏵ 2 | 2022-05-06 07:03:41 | announced | 2022-05-06: Updated publication reference for PubMed record(s): 35439318. |
Publication List
Keyword List
submitter keyword: Human, PARP7, TurboID |
Contact List
Nevan Krogan |
contact affiliation | University of California San Francisco |
contact email | minkyu.kim@ucsf.edu |
lab head | |
Minkyu Kim |
contact affiliation | University of California San Francisco |
contact email | minkyu.kim@ucsf.edu |
dataset submitter | |
Full Dataset Link List
Dataset FTP location
NOTE: Most web browsers have now discontinued native support for FTP access within the browser window. But you can usually install another FTP app (we recommend FileZilla) and configure your browser to launch the external application when you click on this FTP link. Or otherwise, launch an app that supports FTP (like FileZilla) and use this address: ftp://ftp.pride.ebi.ac.uk/pride/data/archive/2022/04/PXD028733 |
PRIDE project URI |
Repository Record List
[ + ]
[ - ]
- PRIDE
- PXD028733
- Label: PRIDE project
- Name: A whole genome CRISPR screen identifies AHR loss as a mechanism of resistance to a PARP7 inhibitor