PXD028716

PXD028716 is an original dataset announced via ProteomeXchange.

Title	Proteomics Deciphering the Underlying Mechanism of Tgfb1 Regulating Dendritic Cells
Description	In current study, we conducted a lentivirus-based overexpression system and observed that overexpressing Tgfb1 successfully promoted the viability and altered the cell cycle distribution in DC. What’s more, this gene also greatly inhibited apoptosis of DC, highlighting the robust immune support effects of Tgfb1 function. Additionally, a quantitative proteomic was implemented to explore the underlying mechanism. Comparing Tgfb1 overexpressed (OE) and normal control (NC) groups, numerous differentially expressed proteins (DEPs) were emerged, which contributed to this phenomenon. Finally, bioinformatics analysis revealed multiple DEPs enriched in immune-related pathways directly or in a roundabout way, which manifested the crucial role played by Tgfb1 in DC.
HostingRepository	iProX
AnnounceDate	2021-09-23
AnnouncementXML	Submission_2021-09-23_00:30:11.316.xml
DigitalObjectIdentifier
ReviewLevel	Peer-reviewed dataset
DatasetOrigin	Original dataset
RepositorySupport	Unsupported dataset by repository
PrimarySubmitter	Yan Zhao
SpeciesList	scientific name: Mus musculus; NCBI TaxID: 10090;
ModificationList	No PTMs are included in the dataset
Instrument	TripleTOF 5600

Revision	Datetime	Status	ChangeLog Entry
0	2021-09-23 00:29:54	ID requested
⏵ 1	2021-09-23 00:30:11	announced

Dataset with its publication pending

submitter keyword: Proteomics, Dendritic Cells, Tgfb1

Yan Zhao
contact affiliation	Hubei Provincial Hospital of Traditional Chinese Medicine
contact email	zhaoyan@hbhtcm.com
lab head
Yan Zhao
contact affiliation	Hubei Provincial Hospital of Traditional Chinese Medicine
contact email	zhaoyan@hbhtcm.com
dataset submitter

iProX dataset URI