PXD028716
PXD028716 is an original dataset announced via ProteomeXchange.
Dataset Summary
Title | Proteomics Deciphering the Underlying Mechanism of Tgfb1 Regulating Dendritic Cells |
Description | In current study, we conducted a lentivirus-based overexpression system and observed that overexpressing Tgfb1 successfully promoted the viability and altered the cell cycle distribution in DC. What’s more, this gene also greatly inhibited apoptosis of DC, highlighting the robust immune support effects of Tgfb1 function. Additionally, a quantitative proteomic was implemented to explore the underlying mechanism. Comparing Tgfb1 overexpressed (OE) and normal control (NC) groups, numerous differentially expressed proteins (DEPs) were emerged, which contributed to this phenomenon. Finally, bioinformatics analysis revealed multiple DEPs enriched in immune-related pathways directly or in a roundabout way, which manifested the crucial role played by Tgfb1 in DC. |
HostingRepository | iProX |
AnnounceDate | 2021-09-23 |
AnnouncementXML | Submission_2021-09-23_00:30:11.316.xml |
DigitalObjectIdentifier | |
ReviewLevel | Peer-reviewed dataset |
DatasetOrigin | Original dataset |
RepositorySupport | Unsupported dataset by repository |
PrimarySubmitter | Yan Zhao |
SpeciesList | scientific name: Mus musculus; NCBI TaxID: 10090; |
ModificationList | No PTMs are included in the dataset |
Instrument | TripleTOF 5600 |
Dataset History
Revision | Datetime | Status | ChangeLog Entry |
---|---|---|---|
0 | 2021-09-23 00:29:54 | ID requested | |
⏵ 1 | 2021-09-23 00:30:11 | announced |
Publication List
Dataset with its publication pending |
Keyword List
submitter keyword: Proteomics, Dendritic Cells, Tgfb1 |
Contact List
Yan Zhao | |
---|---|
contact affiliation | Hubei Provincial Hospital of Traditional Chinese Medicine |
contact email | zhaoyan@hbhtcm.com |
lab head | |
Yan Zhao | |
contact affiliation | Hubei Provincial Hospital of Traditional Chinese Medicine |
contact email | zhaoyan@hbhtcm.com |
dataset submitter |
Full Dataset Link List
iProX dataset URI |