PXD028715

PXD028715 is an original dataset announced via ProteomeXchange.

Title	13C15N – Glucagon-based novel isotope dilution mass spectrometry method for measurement of glucagon metabolism in humans
Description	Glucagon serves as an important regulatory hormone for regulating blood glucose concentrations with tight feedback control with insulin and glucose. There are critical gaps in our understanding of glucagon kinetics, pancreatic α cell function and intra-islet feedback network that are disrupted in type 1 diabetes. This is important for translational research applications of evolving dual-hormone (insulin+glucagon) closed-loop artificial pancreas algorithms and their usage in type 1 diabetes. Thus, it is important to accurately measure glucagon kinetics in vivo and to develop robust models of glucose-insulin-glucagon interplay that could inform next generation of artificial pancreas algorithms.
HostingRepository	PRIDE
AnnounceDate	2022-06-09
AnnouncementXML	Submission_2022-06-09_03:54:58.589.xml
DigitalObjectIdentifier
ReviewLevel	Peer-reviewed dataset
DatasetOrigin	Original dataset
RepositorySupport	Unsupported dataset by repository
PrimarySubmitter	Akhilesh Pandey
SpeciesList	scientific name: Homo sapiens (Human); NCBI TaxID: 9606;
ModificationList	No PTMs are included in the dataset
Instrument	Q Exactive Plus

Revision	Datetime	Status	ChangeLog Entry
0	2021-09-23 00:13:42	ID requested
⏵ 1	2022-06-09 03:55:00	announced

Renuse S, Benson LM, Vanderboom PM, Ruchi FNU, Yadav YR, Johnson KL, Brown BC, Peterson JA, Basu R, McCormick DJ, Pandey A, Basu A, N: glucagon-based novel isotope dilution mass spectrometry method for measurement of glucagon metabolism in humans. Clin Proteomics, 19(1):16(2022) [pubmed]

submitter keyword: Glucagon, stable isotope dilution, LC-MS/MS, PRM

Akhilesh Pandey, M.D., Ph.D.
contact affiliation	Department of Laboratory Medicine and Pathology Mayo Clinic, Rochester
contact email	pandey.akhilesh@mayo.edu
lab head
Akhilesh Pandey
contact affiliation	Department of Laboratory Medicine and Pathology, Mayo Clinic, Rochester, MN 55905
contact email	pandey.akhilesh@mayo.edu
dataset submitter

Dataset FTP location NOTE: Most web browsers have now discontinued native support for FTP access within the browser window. But you can usually install another FTP app (we recommend FileZilla) and configure your browser to launch the external application when you click on this FTP link. Or otherwise, launch an app that supports FTP (like FileZilla) and use this address: ftp://ftp.pride.ebi.ac.uk/pride/data/archive/2022/06/PXD028715

PRIDE project URI

• PRIDE
  1. PXD028715
     1. Label: PRIDE project
     2. Name: 13C15N – Glucagon-based novel isotope dilution mass spectrometry method for measurement of glucagon metabolism in humans