PXD028691

PXD028691 is an original dataset announced via ProteomeXchange.

Title	Elevated N-glycosylation of Membrane Proteins Contributes to the Cisplatin Resistance of Non-small-cell Lung Cancer Cells
Description	Chemoresistance remains to be the major restriction on the clinical use of cisplatin. Aberrant changes in protein glycosylation are closely associated with the growth, invasion, metastasis, and resistance to chemotherapy of cancer cells. Comprehensive study on the role of protein glycosylation in the development of cisplatin resistance would contribute to precise elucidation of the complicated mechanism of resistance. In this work, we have integrated proteomic and N-glycoproteomic analysis for comprehensive identification of the membrane proteins, glycoproteins as well as glycans associated with cisplatin resistance of the non-small-cell lung cancer cells. Using this method, we found that alterations in the abundance and glycosylation of proteins implicated in cell adhesion, cell migration, response to drug and signal transduction occurred in the development of cisplatin resistance. We further assessed the cell migration, invasion, and cellular cisplatin accumulation of the sensitive and resistant cells. Impo
HostingRepository	iProX
AnnounceDate	2021-09-18
AnnouncementXML	Submission_2022-10-19_20:13:28.943.xml
DigitalObjectIdentifier
ReviewLevel	Peer-reviewed dataset
DatasetOrigin	Original dataset
RepositorySupport	Unsupported dataset by repository
PrimarySubmitter	Wenjuan Zeng
SpeciesList	scientific name: Homo sapiens; NCBI TaxID: 9606;
ModificationList	No PTMs are included in the dataset
Instrument	Orbitrap Fusion Lumos

Revision	Datetime	Status	ChangeLog Entry
0	2021-09-21 21:00:15	ID requested
1	2021-09-21 21:00:30	announced
⏵ 2	2022-10-19 20:13:32	announced	2022-10-20: Update publication information.

Zeng W, Zheng S, Mao Y, Wang S, Zhong Y, Cao W, Su T, Gong M, Cheng J, Zhang Y, Yang H, Elevated N-Glycosylation Contributes to the Cisplatin Resistance of Non-Small Cell Lung Cancer Cells Revealed by Membrane Proteomic and Glycoproteomic Analysis. Front Pharmacol, 12():805499(2021) [pubmed]

submitter keyword: N-glycosylation, Cisplatin resistance, Proteomics, N-glycoproteomics

Hao Yang
contact affiliation	West China Hospital, Sichuan University
contact email	yanghao@scu.edu.cn
lab head
Wenjuan Zeng
contact affiliation	West China Hospital, Sichuan University
contact email	zengwj2020@wchscu.cn
dataset submitter

iProX dataset URI