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PXD028689

PXD028689 is an original dataset announced via ProteomeXchange.

Dataset Summary
TitleTHEMIS is a novel substrate and allosteric activator of SHP1, playing dual roles during T cell development
DescriptionBy combining strategies of substrate trapping for PTPs and pupylation-based interaction tagging (PUP-IT) for protein-protein interaction, we develop a systematic proximity labeling methodology PEPSI in identifying novel substrate for PTPs. We apply this approach to SHP1 and surprisingly, identified THEMIS as an uncharacterized substrate for the phosphatase.
HostingRepositoryiProX
AnnounceDate2023-08-31
AnnouncementXMLSubmission_2024-05-22_19:58:18.216.xml
DigitalObjectIdentifier
ReviewLevelPeer-reviewed dataset
DatasetOriginOriginal dataset
RepositorySupportUnsupported dataset by repository
PrimarySubmitterJiali Zhang
SpeciesList scientific name: Homo sapiens; NCBI TaxID: 9606;
ModificationListNo PTMs are included in the dataset
InstrumentQ Exactive HF; Orbitrap Fusion
Dataset History
RevisionDatetimeStatusChangeLog Entry
02021-09-21 19:39:38ID requested
12023-08-31 19:25:40announced
22024-05-22 19:58:19announced2024-05-23: Update information.
Publication List
Zhang J, Jiang Z, Zhang X, Yang Z, Wang J, Chen J, Chen L, Song M, Zhang Y, Huang M, Chen S, Xiong X, Wang Y, Hao P, Horng T, Zhuang M, Zhang L, Zuo E, Bai F, Zheng J, Wang H, Fan G, THEMIS is a substrate and allosteric activator of SHP1, playing dual roles during T cell development. Nat Struct Mol Biol, 31(1):54-67(2024) [pubmed]
Keyword List
submitter keyword: PEPSI, SHP1, THEMIS
Contact List
Gaofeng Fan
contact affiliationShanghaiTech University
contact emailfangf@shanghaitech.edu.cn
lab head
Jiali Zhang
contact affiliationShanghaiTech University
contact emailzhangjl@shanghaitech.edu.cn
dataset submitter
Full Dataset Link List
iProX dataset URI