PXD028689
PXD028689 is an original dataset announced via ProteomeXchange.
Dataset Summary
Title | THEMIS is a novel substrate and allosteric activator of SHP1, playing dual roles during T cell development |
Description | By combining strategies of substrate trapping for PTPs and pupylation-based interaction tagging (PUP-IT) for protein-protein interaction, we develop a systematic proximity labeling methodology PEPSI in identifying novel substrate for PTPs. We apply this approach to SHP1 and surprisingly, identified THEMIS as an uncharacterized substrate for the phosphatase. |
HostingRepository | iProX |
AnnounceDate | 2023-08-31 |
AnnouncementXML | Submission_2024-05-22_19:58:18.216.xml |
DigitalObjectIdentifier | |
ReviewLevel | Peer-reviewed dataset |
DatasetOrigin | Original dataset |
RepositorySupport | Unsupported dataset by repository |
PrimarySubmitter | Jiali Zhang |
SpeciesList | scientific name: Homo sapiens; NCBI TaxID: 9606; |
ModificationList | No PTMs are included in the dataset |
Instrument | Q Exactive HF; Orbitrap Fusion |
Dataset History
Revision | Datetime | Status | ChangeLog Entry |
---|---|---|---|
0 | 2021-09-21 19:39:38 | ID requested | |
1 | 2023-08-31 19:25:40 | announced | |
⏵ 2 | 2024-05-22 19:58:19 | announced | 2024-05-23: Update information. |
Publication List
Zhang J, Jiang Z, Zhang X, Yang Z, Wang J, Chen J, Chen L, Song M, Zhang Y, Huang M, Chen S, Xiong X, Wang Y, Hao P, Horng T, Zhuang M, Zhang L, Zuo E, Bai F, Zheng J, Wang H, Fan G, THEMIS is a substrate and allosteric activator of SHP1, playing dual roles during T cell development. Nat Struct Mol Biol, 31(1):54-67(2024) [pubmed] |
Keyword List
submitter keyword: PEPSI, SHP1, THEMIS |
Contact List
Gaofeng Fan | |
---|---|
contact affiliation | ShanghaiTech University |
contact email | fangf@shanghaitech.edu.cn |
lab head | |
Jiali Zhang | |
contact affiliation | ShanghaiTech University |
contact email | zhangjl@shanghaitech.edu.cn |
dataset submitter |
Full Dataset Link List
iProX dataset URI |