PXD028600

PXD028600 is an original dataset announced via ProteomeXchange.

Title	Proteome of C. elegans upon NCL-1 or TIF-IA KD during aging
Description	Anabolic activities such as ribosome biogenesis and protein synthesis are linked to aging. Ribosomal RNA (rRNA) synthesis is the limiting step of ribosome biogenesis, thus dictating the number of ribosomes in cells and, consequently, the capacity for mRNA translation. Knockdown of the rRNA synthesis repressor, NCL-1, accelerated aging, whereas knocking down the transcription initiation factor C36E8.1 promoted longevity. This suggested that rRNA synthesis has a negative correlation with lifespan. To investigate the metabolic changes upon manipulation of rRNA synthesis the proteome of NCL-1 KD and C36E8.1 KD were analyzed at young, middle, and old age (AD2, AD6, AD12).
HostingRepository	PRIDE
AnnounceDate	2024-10-22
AnnouncementXML	Submission_2024-10-22_06:20:16.143.xml
DigitalObjectIdentifier
ReviewLevel	Peer-reviewed dataset
DatasetOrigin	Original dataset
RepositorySupport	Unsupported dataset by repository
PrimarySubmitter	Emilio Cirri
SpeciesList	scientific name: Caenorhabditis elegans; NCBI TaxID: 6239;
ModificationList	No PTMs are included in the dataset
Instrument	Q Exactive HF-X

Revision	Datetime	Status	ChangeLog Entry
0	2021-09-16 23:40:25	ID requested
1	2024-01-11 03:44:23	announced
⏵ 2	2024-10-22 06:20:16	announced	2024-10-22: Updated project metadata.

Dataset with its publication pending

submitter keyword: rDNA, proteomics, Ribo-aging, rRNA gene transcription,rRNA synthesis, RNA polymerase I

Dr. Holger
contact affiliation	Institut für Biochemie und Biophysik Friedrich-Schiller-Universität Hans-Knöll-Str. 2, D-07745 Jena
contact email	holger.bierhoff@uni-jena.de
lab head
Emilio Cirri
contact affiliation	Leibniz Institute on Ageing Fritz Lipmann Institute Jena
contact email	emilio.cirri@fli-leibniz.de
dataset submitter

Dataset FTP location NOTE: Most web browsers have now discontinued native support for FTP access within the browser window. But you can usually install another FTP app (we recommend FileZilla) and configure your browser to launch the external application when you click on this FTP link. Or otherwise, launch an app that supports FTP (like FileZilla) and use this address: ftp://ftp.pride.ebi.ac.uk/pride/data/archive/2024/01/PXD028600

PRIDE project URI

• PRIDE
  1. PXD028600
     1. Label: PRIDE project
     2. Name: Proteome of C. elegans upon NCL-1 or TIF-IA KD during aging