PXD028561

PXD028561 is an original dataset announced via ProteomeXchange.

Title	Glucose dissociates DDX21 dimers to regulate mRNA splicing and promote epidermal differentiation
Description	We discovered that glucose directly bind to DDX21, induced the conformation change of the proteins and inhibit its helicase activity. Glucose also inhibits the dimerization of DDX21, re-localize DDX21 from nucleolus to nucleoplasm and reassemble DDX21 to RNA splicing complex. DDX21 is essential for epidermal differentiation while with normal glucose condition, DDX21 was re-localized from nucleolus to nucleoplasm, bind to splicing factors and mRNA introns more to regulate splicing of key differentiation factors and promote epidermal differentiation.
HostingRepository	PRIDE
AnnounceDate	2023-11-14
AnnouncementXML	Submission_2023-11-14_08:53:26.174.xml
DigitalObjectIdentifier
ReviewLevel	Peer-reviewed dataset
DatasetOrigin	Original dataset
RepositorySupport	Unsupported dataset by repository
PrimarySubmitter	Yen-Yu Yang
SpeciesList	scientific name: Homo sapiens (Human); NCBI TaxID: 9606;
ModificationList	No PTMs are included in the dataset
Instrument	Q Exactive Plus

Revision	Datetime	Status	ChangeLog Entry
0	2021-09-16 07:40:21	ID requested
1	2023-01-05 19:34:20	announced
⏵ 2	2023-11-14 08:53:26	announced	2023-11-14: Updated project metadata.

Dataset with its publication pending

submitter keyword: Proximity labeling,DDX21, splicing, glucose, BioID, epidermal differentiation

Yinsheng Wang
contact affiliation	Department of Chemistry, University of California Riverside
contact email	yinsheng@ucr.edu
lab head
Yen-Yu Yang
contact affiliation	UC Riverside
contact email	yyang227@ucr.edu
dataset submitter

Dataset FTP location NOTE: Most web browsers have now discontinued native support for FTP access within the browser window. But you can usually install another FTP app (we recommend FileZilla) and configure your browser to launch the external application when you click on this FTP link. Or otherwise, launch an app that supports FTP (like FileZilla) and use this address: ftp://ftp.pride.ebi.ac.uk/pride/data/archive/2023/01/PXD028561

PRIDE project URI

• PRIDE
  1. PXD028561
     1. Label: PRIDE project
     2. Name: Glucose dissociates DDX21 dimers to regulate mRNA splicing and promote epidermal differentiation