PXD028556

PXD028556 is an original dataset announced via ProteomeXchange.

Title	Mitochondrial aconitase (ACO2) modulates iron homeostasis and is associated with outcomes in poor prognosis aggressive non-small cell lung cancer
Description	NSCLC accounts for 85% of lung cancers, the most frequently diagnosed and leading cause of cancer related death. An ACO2-iron acis regulates intracellular iron and consequently the particularly aggressive phenotype associated with NSCLC engraftment and poor prognosis. These findings suggest that NSCLC stratified by ACO2 protein level may benefit from treatments that target iron homeostasis.
HostingRepository	PRIDE
AnnounceDate	2022-09-20
AnnouncementXML	Submission_2022-09-19_17:26:22.394.xml
DigitalObjectIdentifier
ReviewLevel	Peer-reviewed dataset
DatasetOrigin	Original dataset
RepositorySupport	Unsupported dataset by repository
PrimarySubmitter	Shideh Mirhadi
SpeciesList	scientific name: Mus musculus (Mouse); NCBI TaxID: 10090; scientific name: Homo sapiens (Human); NCBI TaxID: 9606;
ModificationList	No PTMs are included in the dataset
Instrument	Q Exactive HF; LTQ Orbitrap

Revision	Datetime	Status	ChangeLog Entry
0	2021-09-16 07:39:46	ID requested
⏵ 1	2022-09-19 17:26:22	announced

Dataset with its publication pending

submitter keyword: ACO2, NSCLC, engraftment, aggressiveness, iron

Michael F. Moran
contact affiliation	The Hospital for Sick Children
contact email	mmoran@sickkids.ca
lab head
Shideh Mirhadi
contact affiliation	Hospital for Sick Children
contact email	shideh.mirhadi@sickkids.ca
dataset submitter

Dataset FTP location NOTE: Most web browsers have now discontinued native support for FTP access within the browser window. But you can usually install another FTP app (we recommend FileZilla) and configure your browser to launch the external application when you click on this FTP link. Or otherwise, launch an app that supports FTP (like FileZilla) and use this address: ftp://ftp.pride.ebi.ac.uk/pride/data/archive/2022/09/PXD028556

PRIDE project URI

• PRIDE
  1. PXD028556
     1. Label: PRIDE project
     2. Name: Mitochondrial aconitase (ACO2) modulates iron homeostasis and is associated with outcomes in poor prognosis aggressive non-small cell lung cancer