PXD028537 is an
original dataset announced via ProteomeXchange.
Dataset Summary
Title | PGRMC1 promotes progestin-dependent proliferation of breast cancer cells by binding prohibitins resulting in activation of ERα signaling |
Description | Combined menopausal hormone therapy is associated with increased breast cancer risk in postmenopausal women. In our previous studies, progesterone receptor membrane component 1 (PGRMC1) was shown to play a role in progestins’ mode of action, resulting in enhanced proliferation of breast cancer cells. Here we describe a potential mechanism by which PGRMC1 contributes to breast cancer progression via interaction with prohibitins, inhibiting their function as transcription factor repressors, thereby facilitating estrogen receptor alpha (ERα) transcriptional activity and enhancing oncogenic signaling upon treatment with certain progestins, such as norethisterone and dydrogesterone. |
HostingRepository | PRIDE |
AnnounceDate | 2022-02-16 |
AnnouncementXML | Submission_2022-02-16_09:45:23.600.xml |
DigitalObjectIdentifier | |
ReviewLevel | Peer-reviewed dataset |
DatasetOrigin | Original dataset |
RepositorySupport | Unsupported dataset by repository |
PrimarySubmitter | Gereon Poschmann |
SpeciesList | scientific name: Homo sapiens (Human); NCBI TaxID: 9606; |
ModificationList | monohydroxylated residue; acetylated residue; iodoacetamide derivatized residue |
Instrument | LTQ Orbitrap Elite |
Dataset History
Revision | Datetime | Status | ChangeLog Entry |
0 | 2021-09-16 06:42:51 | ID requested | |
⏵ 1 | 2022-02-16 09:45:24 | announced | |
Publication List
Bai Y, Ludescher M, Poschmann G, St, ü, hler K, Wyrich M, Oles J, Franken A, Rivandi M, Abramova A, Reinhardt F, Ruckh, ä, berle E, Niederacher D, Fehm T, Cahill MA, Stamm N, Neubauer H, Signaling. Cancers (Basel), 13(22):(2021) [pubmed] |
Keyword List
submitter keyword: PGRMC1, progesterone, progestins, breast cancer, estrogen receptor, hormone therapy, PHB1, PHB2 |
Contact List
Gereon Poschmann |
contact affiliation | Proteome Research (AG Stühler) Institute of Molecular Medicine I Heinrich Heine University Düsseldorf Germany |
contact email | gereon.poschmann@hhu.de |
lab head | |
Gereon Poschmann |
contact affiliation | Molecular Proteomics Laboratory |
contact email | gereon.poschmann@hhu.de |
dataset submitter | |
Full Dataset Link List
Dataset FTP location
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PRIDE project URI |
Repository Record List
[ + ]
[ - ]
- PRIDE
- PXD028537
- Label: PRIDE project
- Name: PGRMC1 promotes progestin-dependent proliferation of breast cancer cells by binding prohibitins resulting in activation of ERα signaling