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PXD028537

PXD028537 is an original dataset announced via ProteomeXchange.

Dataset Summary
TitlePGRMC1 promotes progestin-dependent proliferation of breast cancer cells by binding prohibitins resulting in activation of ERα signaling
DescriptionCombined menopausal hormone therapy is associated with increased breast cancer risk in postmenopausal women. In our previous studies, progesterone receptor membrane component 1 (PGRMC1) was shown to play a role in progestins’ mode of action, resulting in enhanced proliferation of breast cancer cells. Here we describe a potential mechanism by which PGRMC1 contributes to breast cancer progression via interaction with prohibitins, inhibiting their function as transcription factor repressors, thereby facilitating estrogen receptor alpha (ERα) transcriptional activity and enhancing oncogenic signaling upon treatment with certain progestins, such as norethisterone and dydrogesterone.
HostingRepositoryPRIDE
AnnounceDate2022-02-16
AnnouncementXMLSubmission_2022-02-16_09:45:23.600.xml
DigitalObjectIdentifier
ReviewLevelPeer-reviewed dataset
DatasetOriginOriginal dataset
RepositorySupportUnsupported dataset by repository
PrimarySubmitterGereon Poschmann
SpeciesList scientific name: Homo sapiens (Human); NCBI TaxID: 9606;
ModificationListmonohydroxylated residue; acetylated residue; iodoacetamide derivatized residue
InstrumentLTQ Orbitrap Elite
Dataset History
RevisionDatetimeStatusChangeLog Entry
02021-09-16 06:42:51ID requested
12022-02-16 09:45:24announced
Publication List
Bai Y, Ludescher M, Poschmann G, St, ü, hler K, Wyrich M, Oles J, Franken A, Rivandi M, Abramova A, Reinhardt F, Ruckh, ä, berle E, Niederacher D, Fehm T, Cahill MA, Stamm N, Neubauer H, Signaling. Cancers (Basel), 13(22):(2021) [pubmed]
Keyword List
submitter keyword: PGRMC1, progesterone, progestins, breast cancer, estrogen receptor, hormone therapy, PHB1, PHB2
Contact List
Gereon Poschmann
contact affiliationProteome Research (AG Stühler) Institute of Molecular Medicine I Heinrich Heine University Düsseldorf Germany
contact emailgereon.poschmann@hhu.de
lab head
Gereon Poschmann
contact affiliationMolecular Proteomics Laboratory
contact emailgereon.poschmann@hhu.de
dataset submitter
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Dataset FTP location
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