PXD028532 is an
original dataset announced via ProteomeXchange.
Dataset Summary
Title | Proteome of human branching and non-branching cholangiocyte organoids |
Description | Current model systems for studying intrahepatic biliary disease fail to recapitulate the architecture of intrahepatic bile ducts. Organoids from intrahepatic cholangiocytes can with a new culture method grow with a branching pattern resembling the structure of intrahepatic bile ducts. This dataset contains data from samples of these organoids and from control organoids cultured without this technique. Culture have been performed using isotope labeled amino acids to help distinguish cell derived proteins from the basement membrane extract used as a culture substrate for the organoids. |
HostingRepository | PRIDE |
AnnounceDate | 2022-05-09 |
AnnouncementXML | Submission_2022-05-08_23:19:29.630.xml |
DigitalObjectIdentifier | https://dx.doi.org/10.6019/PXD028532 |
ReviewLevel | Peer-reviewed dataset |
DatasetOrigin | Original dataset |
RepositorySupport | Supported dataset by repository |
PrimarySubmitter | Oskar Rosmark |
SpeciesList | scientific name: Homo sapiens (Human); NCBI TaxID: 9606; |
ModificationList | acetylated residue; monohydroxylated residue; iodoacetamide derivatized residue; deamidated residue |
Instrument | Orbitrap Fusion |
Dataset History
Revision | Datetime | Status | ChangeLog Entry |
0 | 2021-09-16 06:42:16 | ID requested | |
⏵ 1 | 2022-05-08 23:19:30 | announced | |
Publication List
Roos FJM, van Tienderen GS, Wu H, Bordeu I, Vinke D, Albarinos LM, Monfils K, Niesten S, Smits R, Willemse J, Rosmark O, Westergren-Thorsson G, Kunz DJ, de Wit M, French PJ, Vallier L, IJzermans JNM, Bartfai R, Marks H, Simons BD, van Royen ME, Verstegen MMA, van der Laan LJW, Human branching cholangiocyte organoids recapitulate functional bile duct formation. Cell Stem Cell, 29(5):776-794.e13(2022) [pubmed] |
Keyword List
submitter keyword: Cholangiocyte organoids, branching morphogenesis, cholangiocarcinoma, disease modelling, cholangiocytes, intrahepatic bile duct, embryonic development |
Contact List
Prof. Luc van der Laan |
contact affiliation | Department of Surgery, Erasmus MC-University Medical Center, Rotterdam, The Netherlands. |
contact email | l.vanderlaan@erasmusmc.nl |
lab head | |
Oskar Rosmark |
contact affiliation | Lung Biology, Department Experimental Medical Science, Lund University, Lund, Sweden. |
contact email | oskar.rosmark@med.lu.se |
dataset submitter | |
Full Dataset Link List
Dataset FTP location
NOTE: Most web browsers have now discontinued native support for FTP access within the browser window. But you can usually install another FTP app (we recommend FileZilla) and configure your browser to launch the external application when you click on this FTP link. Or otherwise, launch an app that supports FTP (like FileZilla) and use this address: ftp://ftp.pride.ebi.ac.uk/pride/data/archive/2022/05/PXD028532 |
PRIDE project URI |
Repository Record List
[ + ]
[ - ]
- PRIDE
- PXD028532
- Label: PRIDE project
- Name: Proteome of human branching and non-branching cholangiocyte organoids