PXD028532

PXD028532 is an original dataset announced via ProteomeXchange.

Title	Proteome of human branching and non-branching cholangiocyte organoids
Description	Current model systems for studying intrahepatic biliary disease fail to recapitulate the architecture of intrahepatic bile ducts. Organoids from intrahepatic cholangiocytes can with a new culture method grow with a branching pattern resembling the structure of intrahepatic bile ducts. This dataset contains data from samples of these organoids and from control organoids cultured without this technique. Culture have been performed using isotope labeled amino acids to help distinguish cell derived proteins from the basement membrane extract used as a culture substrate for the organoids.
HostingRepository	PRIDE
AnnounceDate	2022-05-09
AnnouncementXML	Submission_2022-05-08_23:19:29.630.xml
DigitalObjectIdentifier	https://dx.doi.org/10.6019/PXD028532
ReviewLevel	Peer-reviewed dataset
DatasetOrigin	Original dataset
RepositorySupport	Supported dataset by repository
PrimarySubmitter	Oskar Rosmark
SpeciesList	scientific name: Homo sapiens (Human); NCBI TaxID: 9606;
ModificationList	acetylated residue; monohydroxylated residue; iodoacetamide derivatized residue; deamidated residue
Instrument	Orbitrap Fusion

Revision	Datetime	Status	ChangeLog Entry
0	2021-09-16 06:42:16	ID requested
⏵ 1	2022-05-08 23:19:30	announced

Roos FJM, van Tienderen GS, Wu H, Bordeu I, Vinke D, Albarinos LM, Monfils K, Niesten S, Smits R, Willemse J, Rosmark O, Westergren-Thorsson G, Kunz DJ, de Wit M, French PJ, Vallier L, IJzermans JNM, Bartfai R, Marks H, Simons BD, van Royen ME, Verstegen MMA, van der Laan LJW, Human branching cholangiocyte organoids recapitulate functional bile duct formation. Cell Stem Cell, 29(5):776-794.e13(2022) [pubmed]

submitter keyword: Cholangiocyte organoids, branching morphogenesis, cholangiocarcinoma, disease modelling, cholangiocytes, intrahepatic bile duct, embryonic development

Prof. Luc van der Laan
contact affiliation	Department of Surgery, Erasmus MC-University Medical Center, Rotterdam, The Netherlands.
contact email	l.vanderlaan@erasmusmc.nl
lab head
Oskar Rosmark
contact affiliation	Lung Biology, Department Experimental Medical Science, Lund University, Lund, Sweden.
contact email	oskar.rosmark@med.lu.se
dataset submitter

Dataset FTP location NOTE: Most web browsers have now discontinued native support for FTP access within the browser window. But you can usually install another FTP app (we recommend FileZilla) and configure your browser to launch the external application when you click on this FTP link. Or otherwise, launch an app that supports FTP (like FileZilla) and use this address: ftp://ftp.pride.ebi.ac.uk/pride/data/archive/2022/05/PXD028532

PRIDE project URI

• PRIDE
  1. PXD028532
     1. Label: PRIDE project
     2. Name: Proteome of human branching and non-branching cholangiocyte organoids