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PXD028532

PXD028532 is an original dataset announced via ProteomeXchange.

Dataset Summary
TitleProteome of human branching and non-branching cholangiocyte organoids
DescriptionCurrent model systems for studying intrahepatic biliary disease fail to recapitulate the architecture of intrahepatic bile ducts. Organoids from intrahepatic cholangiocytes can with a new culture method grow with a branching pattern resembling the structure of intrahepatic bile ducts. This dataset contains data from samples of these organoids and from control organoids cultured without this technique. Culture have been performed using isotope labeled amino acids to help distinguish cell derived proteins from the basement membrane extract used as a culture substrate for the organoids.
HostingRepositoryPRIDE
AnnounceDate2022-05-09
AnnouncementXMLSubmission_2022-05-08_23:19:29.630.xml
DigitalObjectIdentifierhttps://dx.doi.org/10.6019/PXD028532
ReviewLevelPeer-reviewed dataset
DatasetOriginOriginal dataset
RepositorySupportSupported dataset by repository
PrimarySubmitterOskar Rosmark
SpeciesList scientific name: Homo sapiens (Human); NCBI TaxID: 9606;
ModificationListacetylated residue; monohydroxylated residue; iodoacetamide derivatized residue; deamidated residue
InstrumentOrbitrap Fusion
Dataset History
RevisionDatetimeStatusChangeLog Entry
02021-09-16 06:42:16ID requested
12022-05-08 23:19:30announced
Publication List
Roos FJM, van Tienderen GS, Wu H, Bordeu I, Vinke D, Albarinos LM, Monfils K, Niesten S, Smits R, Willemse J, Rosmark O, Westergren-Thorsson G, Kunz DJ, de Wit M, French PJ, Vallier L, IJzermans JNM, Bartfai R, Marks H, Simons BD, van Royen ME, Verstegen MMA, van der Laan LJW, Human branching cholangiocyte organoids recapitulate functional bile duct formation. Cell Stem Cell, 29(5):776-794.e13(2022) [pubmed]
Keyword List
submitter keyword: Cholangiocyte organoids, branching morphogenesis, cholangiocarcinoma, disease modelling, cholangiocytes, intrahepatic bile duct, embryonic development
Contact List
Prof. Luc van der Laan
contact affiliationDepartment of Surgery, Erasmus MC-University Medical Center, Rotterdam, The Netherlands.
contact emaill.vanderlaan@erasmusmc.nl
lab head
Oskar Rosmark
contact affiliationLung Biology, Department Experimental Medical Science, Lund University, Lund, Sweden.
contact emailoskar.rosmark@med.lu.se
dataset submitter
Full Dataset Link List
Dataset FTP location
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PRIDE project URI
Repository Record List
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